Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective study
Importance Identifying undetected clinical signs is imperative in the prevention of SARS-CoV-2.Objective To establish the prevalence of clinical gustatory and olfactory dysfunctions in patients with COVID-19 pneumonia. Clinical outcomes and recovery rates associated with gustatory and olfactory dysf...
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BMJ Publishing Group
2021-08-01
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| author | Felipe García Ana González Cordón Pedro Puerta-Alcalde Celia Cardozo Carolina Garcia-Vidal Marta Bodro Isam Alobid Juan Ambrosioni Jhon Rojas Alexy Inciarte Berta Torres Alex Soriano José Antonio Martínez Josep Mensa Marta Hernández-Meneses Laura Morata Mariana Chumbita Pau Alcubilla Veronica Rico Daiana Aguero Nicole García-Pouton Laia Albiach Fernanda Meira Lorena De la Mora laura Linares Irene Macaya Montse Laguno Angela Ramos Estela Moreno-García Antonio Moreno Montse Sola Lorna Leal Manuel Torres |
| author_facet | Felipe García Ana González Cordón Pedro Puerta-Alcalde Celia Cardozo Carolina Garcia-Vidal Marta Bodro Isam Alobid Juan Ambrosioni Jhon Rojas Alexy Inciarte Berta Torres Alex Soriano José Antonio Martínez Josep Mensa Marta Hernández-Meneses Laura Morata Mariana Chumbita Pau Alcubilla Veronica Rico Daiana Aguero Nicole García-Pouton Laia Albiach Fernanda Meira Lorena De la Mora laura Linares Irene Macaya Montse Laguno Angela Ramos Estela Moreno-García Antonio Moreno Montse Sola Lorna Leal Manuel Torres |
| author_sort | Felipe García |
| collection | DOAJ |
| description | Importance Identifying undetected clinical signs is imperative in the prevention of SARS-CoV-2.Objective To establish the prevalence of clinical gustatory and olfactory dysfunctions in patients with COVID-19 pneumonia. Clinical outcomes and recovery rates associated with gustatory and olfactory dysfunctions were also assessed.Design A prospective study was performed in 80 patients admitted to Hospital Clínic of Barcelona (Spain) for COVID-19 pneumonia. Patients were re-evaluated in the ward daily until discharge. Gustatory and olfactory dysfunction symptoms were retrospectively collected from emergency room (ER) charts after first assessments. Follow-up was performed in telemedicine consultation.Setting The single-centre study was performed in a hospitalisation ward at a university hospital.Participants Consecutive patients meeting hospitalisation criteria for COVID-19 pneumonia were eligible. Study exclusion criteria were patients who could not speak, had previous gustatory and olfactory dysfunctions or whose PCR tests for SARS-CoV-19 were negative.Interventions Systematic assessment of gustatory and olfactory symptoms with standardised questions.Outcome(s) Prevalence of gustatory and olfactory dysfunctions in patients with COVID-19 pneumonia.Results Of the 80 study subjects, 62.5% were male and the median age was 57 years. Half of the cohort (n=40) presented with comorbidities. The prevalence of chemosensitive disorder was 73.8% (n=59) (95% CI: 63.8 to 83.8), although self-reported symptoms were recorded in only 26.3% (n=21) of patients in the ER. Gustatory and olfactory dysfunctions were observed in 58.8% (n=47) and 55% (n=44) of cases, respectively. They were also the first symptoms in 25% (n=20) of patients. Anosmia was associated with ageusia, OR: 7, 95% CI: 2.3 to 21.8, p=0.001). No differences in clinical outcomes were observed when patients with and without gustatory and olfactory dysfunctions were compared. Recovery rates were 20% (n=10) and 85% (n=42) at days 7 and 45, respectively.Conclusion The prevalence of gustatory and olfactory dysfunctions in COVID-19 pneumonia was much higher than in self-report. Presence of gustatory and olfactory dysfunctions was not a predictor of clinical outcomes. |
| format | Article |
| id | doaj-art-7be9b6443cbb4f6ea985ac53fac037ec |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7be9b6443cbb4f6ea985ac53fac037ec2025-08-20T01:54:58ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2020-040775Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective studyFelipe García0Ana González Cordón1Pedro Puerta-Alcalde2Celia Cardozo3Carolina Garcia-Vidal4Marta Bodro5Isam Alobid6Juan Ambrosioni7Jhon Rojas8Alexy Inciarte9Berta Torres10Alex Soriano11José Antonio Martínez12Josep Mensa13Marta Hernández-Meneses14Laura Morata15Mariana Chumbita16Pau Alcubilla17Veronica Rico18Daiana Aguero19Nicole García-Pouton20Laia Albiach21Fernanda Meira22Lorena De la Mora23laura Linares24Irene Macaya25Montse Laguno26Angela Ramos27Estela Moreno-García28Antonio Moreno29Montse Sola30Lorna Leal31Manuel Torres32Faculty of Medicine and Health Sciencies, University of Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainHospital Clínic, Rheumatology, Barcelona, SpainFaculty of Medicine and Health Sciencies, University of Barcelona, Barcelona, SpainRhinology Unit & Smell Clinic, ENT Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainFaculty of Medicine and Health Sciencies, University of Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainAIDS and HIV infection, Institut d`Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainAIDS and HIV infection, Institut d`Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, SpainAIDS and HIV infection, Institut d`Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainAIDS and HIV infection, Institut d`Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainInfectious Diseases Department, Hospital Clinic de Barcelona, Barcelona, SpainImportance Identifying undetected clinical signs is imperative in the prevention of SARS-CoV-2.Objective To establish the prevalence of clinical gustatory and olfactory dysfunctions in patients with COVID-19 pneumonia. Clinical outcomes and recovery rates associated with gustatory and olfactory dysfunctions were also assessed.Design A prospective study was performed in 80 patients admitted to Hospital Clínic of Barcelona (Spain) for COVID-19 pneumonia. Patients were re-evaluated in the ward daily until discharge. Gustatory and olfactory dysfunction symptoms were retrospectively collected from emergency room (ER) charts after first assessments. Follow-up was performed in telemedicine consultation.Setting The single-centre study was performed in a hospitalisation ward at a university hospital.Participants Consecutive patients meeting hospitalisation criteria for COVID-19 pneumonia were eligible. Study exclusion criteria were patients who could not speak, had previous gustatory and olfactory dysfunctions or whose PCR tests for SARS-CoV-19 were negative.Interventions Systematic assessment of gustatory and olfactory symptoms with standardised questions.Outcome(s) Prevalence of gustatory and olfactory dysfunctions in patients with COVID-19 pneumonia.Results Of the 80 study subjects, 62.5% were male and the median age was 57 years. Half of the cohort (n=40) presented with comorbidities. The prevalence of chemosensitive disorder was 73.8% (n=59) (95% CI: 63.8 to 83.8), although self-reported symptoms were recorded in only 26.3% (n=21) of patients in the ER. Gustatory and olfactory dysfunctions were observed in 58.8% (n=47) and 55% (n=44) of cases, respectively. They were also the first symptoms in 25% (n=20) of patients. Anosmia was associated with ageusia, OR: 7, 95% CI: 2.3 to 21.8, p=0.001). No differences in clinical outcomes were observed when patients with and without gustatory and olfactory dysfunctions were compared. Recovery rates were 20% (n=10) and 85% (n=42) at days 7 and 45, respectively.Conclusion The prevalence of gustatory and olfactory dysfunctions in COVID-19 pneumonia was much higher than in self-report. Presence of gustatory and olfactory dysfunctions was not a predictor of clinical outcomes.https://bmjopen.bmj.com/content/11/8/e040775.full |
| spellingShingle | Felipe García Ana González Cordón Pedro Puerta-Alcalde Celia Cardozo Carolina Garcia-Vidal Marta Bodro Isam Alobid Juan Ambrosioni Jhon Rojas Alexy Inciarte Berta Torres Alex Soriano José Antonio Martínez Josep Mensa Marta Hernández-Meneses Laura Morata Mariana Chumbita Pau Alcubilla Veronica Rico Daiana Aguero Nicole García-Pouton Laia Albiach Fernanda Meira Lorena De la Mora laura Linares Irene Macaya Montse Laguno Angela Ramos Estela Moreno-García Antonio Moreno Montse Sola Lorna Leal Manuel Torres Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective study BMJ Open |
| title | Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective study |
| title_full | Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective study |
| title_fullStr | Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective study |
| title_full_unstemmed | Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective study |
| title_short | Gustatory and olfactory dysfunctions in hospitalised patients with COVID-19 pneumonia: a prospective study |
| title_sort | gustatory and olfactory dysfunctions in hospitalised patients with covid 19 pneumonia a prospective study |
| url | https://bmjopen.bmj.com/content/11/8/e040775.full |
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