Visualization Methods for DNA Sequences: A Review and Prospects
The efficient analysis and interpretation of biological sequence data remain major challenges in bioinformatics. Graphical representation, as an emerging and effective visualization technique, offers a more intuitive method for analyzing DNA sequences. However, many visualization approaches are disp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/11/1447 |
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| author | Tan Li Mengshan Li Yan Wu Yelin Li |
| author_facet | Tan Li Mengshan Li Yan Wu Yelin Li |
| author_sort | Tan Li |
| collection | DOAJ |
| description | The efficient analysis and interpretation of biological sequence data remain major challenges in bioinformatics. Graphical representation, as an emerging and effective visualization technique, offers a more intuitive method for analyzing DNA sequences. However, many visualization approaches are dispersed across research databases, requiring urgent organization, integration, and analysis. Additionally, no single visualization method excels in all aspects. To advance these methods, knowledge graphs and advanced machine learning techniques have become key areas of exploration. This paper reviews the current 2D and 3D DNA sequence visualization methods and proposes a new research direction focused on constructing knowledge graphs for biological sequence visualization, explaining the relevant theories, techniques, and models involved. Additionally, we summarize machine learning techniques applicable to sequence visualization, such as graph embedding methods and the use of convolutional neural networks (CNNs) for processing graphical representations. These machine learning techniques and knowledge graphs aim to provide valuable insights into computational biology, bioinformatics, genomic computing, and evolutionary analysis. The study serves as an important reference for improving intelligent search systems, enriching knowledge bases, and enhancing query systems related to biological sequence visualization, offering a comprehensive framework for future research. |
| format | Article |
| id | doaj-art-7be942d7441e4208bda37df7322fb301 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-7be942d7441e4208bda37df7322fb3012025-08-20T02:08:02ZengMDPI AGBiomolecules2218-273X2024-11-011411144710.3390/biom14111447Visualization Methods for DNA Sequences: A Review and ProspectsTan Li0Mengshan Li1Yan Wu2Yelin Li3School of Physics and Electronic Information, Gannan Normal University, Ganzhou 341000, ChinaSchool of Physics and Electronic Information, Gannan Normal University, Ganzhou 341000, ChinaSchool of Mathematics and Computer Science, Gannan Normal University, Ganzhou 341000, ChinaSchool of Physics and Electronic Information, Gannan Normal University, Ganzhou 341000, ChinaThe efficient analysis and interpretation of biological sequence data remain major challenges in bioinformatics. Graphical representation, as an emerging and effective visualization technique, offers a more intuitive method for analyzing DNA sequences. However, many visualization approaches are dispersed across research databases, requiring urgent organization, integration, and analysis. Additionally, no single visualization method excels in all aspects. To advance these methods, knowledge graphs and advanced machine learning techniques have become key areas of exploration. This paper reviews the current 2D and 3D DNA sequence visualization methods and proposes a new research direction focused on constructing knowledge graphs for biological sequence visualization, explaining the relevant theories, techniques, and models involved. Additionally, we summarize machine learning techniques applicable to sequence visualization, such as graph embedding methods and the use of convolutional neural networks (CNNs) for processing graphical representations. These machine learning techniques and knowledge graphs aim to provide valuable insights into computational biology, bioinformatics, genomic computing, and evolutionary analysis. The study serves as an important reference for improving intelligent search systems, enriching knowledge bases, and enhancing query systems related to biological sequence visualization, offering a comprehensive framework for future research.https://www.mdpi.com/2218-273X/14/11/1447computational biologyvisualization methodgraphical representationknowledge graphmachine learning |
| spellingShingle | Tan Li Mengshan Li Yan Wu Yelin Li Visualization Methods for DNA Sequences: A Review and Prospects Biomolecules computational biology visualization method graphical representation knowledge graph machine learning |
| title | Visualization Methods for DNA Sequences: A Review and Prospects |
| title_full | Visualization Methods for DNA Sequences: A Review and Prospects |
| title_fullStr | Visualization Methods for DNA Sequences: A Review and Prospects |
| title_full_unstemmed | Visualization Methods for DNA Sequences: A Review and Prospects |
| title_short | Visualization Methods for DNA Sequences: A Review and Prospects |
| title_sort | visualization methods for dna sequences a review and prospects |
| topic | computational biology visualization method graphical representation knowledge graph machine learning |
| url | https://www.mdpi.com/2218-273X/14/11/1447 |
| work_keys_str_mv | AT tanli visualizationmethodsfordnasequencesareviewandprospects AT mengshanli visualizationmethodsfordnasequencesareviewandprospects AT yanwu visualizationmethodsfordnasequencesareviewandprospects AT yelinli visualizationmethodsfordnasequencesareviewandprospects |