The impact of comorbidity on mortality in Danish sarcoma patients from 2000-2013: A nationwide population-based multicentre study.
<h4>Introduction</h4>Sarcoma is a rare type of cancer. The incidence increases with age and elderly patients may have comorbidity that affects the prognosis. The aim of this study was to describe the type and prevalence of comorbidity in a nationwide population-based study in Denmark fro...
Saved in:
| _version_ | 1850076662513795072 |
|---|---|
| author | Mathias Raedkjaer Katja Maretty-Kongstad Thomas Baad-Hansen Peter Holmberg Jørgensen Akmal Safwat Peter Vedsted Michael Mørk Petersen Thea Hovgaard Tine Nymark Johnny Keller |
| author_facet | Mathias Raedkjaer Katja Maretty-Kongstad Thomas Baad-Hansen Peter Holmberg Jørgensen Akmal Safwat Peter Vedsted Michael Mørk Petersen Thea Hovgaard Tine Nymark Johnny Keller |
| author_sort | Mathias Raedkjaer |
| collection | DOAJ |
| description | <h4>Introduction</h4>Sarcoma is a rare type of cancer. The incidence increases with age and elderly patients may have comorbidity that affects the prognosis. The aim of this study was to describe the type and prevalence of comorbidity in a nationwide population-based study in Denmark from 2000-2013 and to analyse the impact of the different comorbidities on mortality.<h4>Material and methods</h4>The Danish Sarcoma Registry is a national clinical database containing all patients with sarcoma in the extremities or trunk wall from 2000 and onwards. By linking data to other registries, we were able to get patient information on an individual level including date and cause of death as well as the comorbidity type up to 10 years prior to the sarcoma diagnosis. Based on diseases in the Charlson Comorbidity Index, we pooled the patients into six categories: no comorbidity, cardiopulmonary disease, gastrointestinal disease, neurovascular disease, malignant neoplasms, and miscellaneous (diabetes, renal and connective tissue diseases). 2167 patients were included.<h4>Results</h4>The prevalence of comorbidity was 20%. For patients with localized disease, comorbidity increased the disease-specific mortality significantly (HR 1.70 (95% CI 1.36-2.13)). For patients with metastatic disease at the time of diagnosis, comorbidity did not affect the disease-specific mortality (HR 1.05 (95% CI 0.78-1.42)). The presence of another cancer diagnosis within 10 years prior to the sarcoma diagnosis was the only significant independent prognostic factor of disease-specific mortality with an increase of 66% in mortality rate compared to patients with no comorbidity (HR 1,66 (95% CI 1.22-2.25)).<h4>Conclusion</h4>Comorbidity is a strong independent prognostic factor of mortality in patients with localized disease. This study emphasizes the need for optimizing the general health of comorbid patients in order to achieve a survival benefit from treatment of patients with localized disease, as this is potentially modifiable. |
| format | Article |
| id | doaj-art-7be4acf1a7444f8b8f54b6a9328e5e36 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7be4acf1a7444f8b8f54b6a9328e5e362025-08-20T02:45:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01136e019893310.1371/journal.pone.0198933The impact of comorbidity on mortality in Danish sarcoma patients from 2000-2013: A nationwide population-based multicentre study.Mathias RaedkjaerKatja Maretty-KongstadThomas Baad-HansenPeter Holmberg JørgensenAkmal SafwatPeter VedstedMichael Mørk PetersenThea HovgaardTine NymarkJohnny Keller<h4>Introduction</h4>Sarcoma is a rare type of cancer. The incidence increases with age and elderly patients may have comorbidity that affects the prognosis. The aim of this study was to describe the type and prevalence of comorbidity in a nationwide population-based study in Denmark from 2000-2013 and to analyse the impact of the different comorbidities on mortality.<h4>Material and methods</h4>The Danish Sarcoma Registry is a national clinical database containing all patients with sarcoma in the extremities or trunk wall from 2000 and onwards. By linking data to other registries, we were able to get patient information on an individual level including date and cause of death as well as the comorbidity type up to 10 years prior to the sarcoma diagnosis. Based on diseases in the Charlson Comorbidity Index, we pooled the patients into six categories: no comorbidity, cardiopulmonary disease, gastrointestinal disease, neurovascular disease, malignant neoplasms, and miscellaneous (diabetes, renal and connective tissue diseases). 2167 patients were included.<h4>Results</h4>The prevalence of comorbidity was 20%. For patients with localized disease, comorbidity increased the disease-specific mortality significantly (HR 1.70 (95% CI 1.36-2.13)). For patients with metastatic disease at the time of diagnosis, comorbidity did not affect the disease-specific mortality (HR 1.05 (95% CI 0.78-1.42)). The presence of another cancer diagnosis within 10 years prior to the sarcoma diagnosis was the only significant independent prognostic factor of disease-specific mortality with an increase of 66% in mortality rate compared to patients with no comorbidity (HR 1,66 (95% CI 1.22-2.25)).<h4>Conclusion</h4>Comorbidity is a strong independent prognostic factor of mortality in patients with localized disease. This study emphasizes the need for optimizing the general health of comorbid patients in order to achieve a survival benefit from treatment of patients with localized disease, as this is potentially modifiable.https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198933/1/pone.0198933.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134519Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=45ee68c19ef3838584d2945fd695c654e4ff32a039a87eed52227b70bf5a80fae31063031a336e69cae3c7d610ffd8164fc3b33703e1e69741723b5b691912de6a97dcb5e610772addc99a72e745fd5e4a5a226212b6997eb0720bca1e2509537d08118421f001d41a53be50ed50a59c36d3feff0ef40bde471127d510b97ad0b2407400239b284723bd6d2606d13be67ab827de8f6aadda5788c6fa2e7eee24ea8af8e2d8b31014b8aa8a45142d5f6067ec1c5b1f92a79ca82b287551d63813cb5f63f6c0a0a3cea8a40d9a7b930487a84004cfc4f5af74bb7f591c255e2904b5b5dea9e1062a792eb40e4f0a9731a27ccb2071ab4afd96afb8c3ec91631430 |
| spellingShingle | Mathias Raedkjaer Katja Maretty-Kongstad Thomas Baad-Hansen Peter Holmberg Jørgensen Akmal Safwat Peter Vedsted Michael Mørk Petersen Thea Hovgaard Tine Nymark Johnny Keller The impact of comorbidity on mortality in Danish sarcoma patients from 2000-2013: A nationwide population-based multicentre study. PLoS ONE |
| title | The impact of comorbidity on mortality in Danish sarcoma patients from 2000-2013: A nationwide population-based multicentre study. |
| title_full | The impact of comorbidity on mortality in Danish sarcoma patients from 2000-2013: A nationwide population-based multicentre study. |
| title_fullStr | The impact of comorbidity on mortality in Danish sarcoma patients from 2000-2013: A nationwide population-based multicentre study. |
| title_full_unstemmed | The impact of comorbidity on mortality in Danish sarcoma patients from 2000-2013: A nationwide population-based multicentre study. |
| title_short | The impact of comorbidity on mortality in Danish sarcoma patients from 2000-2013: A nationwide population-based multicentre study. |
| title_sort | impact of comorbidity on mortality in danish sarcoma patients from 2000 2013 a nationwide population based multicentre study |
| url | https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198933/1/pone.0198933.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134519Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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 |
| work_keys_str_mv | AT mathiasraedkjaer theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT katjamarettykongstad theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT thomasbaadhansen theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT peterholmbergjørgensen theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT akmalsafwat theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT petervedsted theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT michaelmørkpetersen theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT theahovgaard theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT tinenymark theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT johnnykeller theimpactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT mathiasraedkjaer impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT katjamarettykongstad impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT thomasbaadhansen impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT peterholmbergjørgensen impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT akmalsafwat impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT petervedsted impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT michaelmørkpetersen impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT theahovgaard impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT tinenymark impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy AT johnnykeller impactofcomorbidityonmortalityindanishsarcomapatientsfrom20002013anationwidepopulationbasedmulticentrestudy |