Lymph Node Transplantation and Its Immunological Significance in Animal Models
Lymph nodes (LNs) are distributed all over the body and whatever the site consists of the same cell populations. However, there are great differences between LN from different draining areas. For example, in mesenteric LN, homing molecules, for example, CCR9 and α4β7 integrin, were induced and cytok...
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| Format: | Article |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/353510 |
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| author | Manuela Buettner Ulrike Bode |
| author_facet | Manuela Buettner Ulrike Bode |
| author_sort | Manuela Buettner |
| collection | DOAJ |
| description | Lymph nodes (LNs) are distributed all over the body and whatever the site consists of the same cell populations. However, there are great differences between LN from different draining areas. For example, in mesenteric LN, homing molecules, for example, CCR9 and α4β7 integrin, were induced and cytokines, for example, IL-4, were produced on higher levels compared to peripheral LN. To study the immunological functions of LN, LN transplantation was performed in some specific areas using different animal models. Many groups investigated not only the regeneration of transplanted LN but also the induction of immune responses or tolerance after transplantation. Existing differences between LNs were still detectable after transplantation. Most important, stromal cells of the LN were identified as responsible for these differences. They survive during regeneration and were shown to reconstruct not only the structure of the new LN but also the microenvironment. |
| format | Article |
| id | doaj-art-7be48a7bfa8f4e68accc819c1e69b6a5 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-7be48a7bfa8f4e68accc819c1e69b6a52025-08-20T02:06:53ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/353510353510Lymph Node Transplantation and Its Immunological Significance in Animal ModelsManuela Buettner0Ulrike Bode1Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, GermanyInstitute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, GermanyLymph nodes (LNs) are distributed all over the body and whatever the site consists of the same cell populations. However, there are great differences between LN from different draining areas. For example, in mesenteric LN, homing molecules, for example, CCR9 and α4β7 integrin, were induced and cytokines, for example, IL-4, were produced on higher levels compared to peripheral LN. To study the immunological functions of LN, LN transplantation was performed in some specific areas using different animal models. Many groups investigated not only the regeneration of transplanted LN but also the induction of immune responses or tolerance after transplantation. Existing differences between LNs were still detectable after transplantation. Most important, stromal cells of the LN were identified as responsible for these differences. They survive during regeneration and were shown to reconstruct not only the structure of the new LN but also the microenvironment.http://dx.doi.org/10.1155/2011/353510 |
| spellingShingle | Manuela Buettner Ulrike Bode Lymph Node Transplantation and Its Immunological Significance in Animal Models Clinical and Developmental Immunology |
| title | Lymph Node Transplantation and Its Immunological Significance in Animal Models |
| title_full | Lymph Node Transplantation and Its Immunological Significance in Animal Models |
| title_fullStr | Lymph Node Transplantation and Its Immunological Significance in Animal Models |
| title_full_unstemmed | Lymph Node Transplantation and Its Immunological Significance in Animal Models |
| title_short | Lymph Node Transplantation and Its Immunological Significance in Animal Models |
| title_sort | lymph node transplantation and its immunological significance in animal models |
| url | http://dx.doi.org/10.1155/2011/353510 |
| work_keys_str_mv | AT manuelabuettner lymphnodetransplantationanditsimmunologicalsignificanceinanimalmodels AT ulrikebode lymphnodetransplantationanditsimmunologicalsignificanceinanimalmodels |