CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury

CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury

Abstract Background Myocardial ischemia/reperfusion injury (MIRI) secondary to acute myocardial infarction (AMI) can lead to cardiomyocyte death and impaired cardiac function. Studies have confirmed that circular RNAs (circRNAs) play an important role in MIRI. In this study, the role and mechanism o...

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Bibliographic Details
Main Authors: Zhu Zhang, Jinqi Hao, Qinghong Qiao, Junting Song, Yanqin Yu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Cardiothoracic Surgery
Subjects:
CircHIPK2
SRSF1
TXNIP
Ferroptosis
Myocardial ischemia-reperfusion injury
Online Access:https://doi.org/10.1186/s13019-024-03325-2
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