Impact of host factors and invasive meningococci on bacterial adhesion, proliferation, primary nasal epithelial barrier function, and immune response

Impact of host factors and invasive meningococci on bacterial adhesion, proliferation, primary nasal epithelial barrier function, and immune response

ABSTRACT Neisseria meningitidis colonizes the human upper airway mucosa, which can progress into invasive meningococcal disease (IMD) upon breaching the epithelial barrier. Some serogroups and lineages are associated with IMD, whereas others rarely infect patients. Although multiple virulence factor...

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Bibliographic Details
Main Authors: Daan W. Arends, Debbie van Rooijen, Esther van Woudenbergh, Janine Wolf, Milou Ohm, Marien I. de Jonge, Gerco den Hartog
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
Neisseria meningitidis
host-pathogen interactions
primary epithelial cells
respiratory pathogens
gram-negative bacteria
meningococcus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00141-25
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