Betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving NADPH/FTO/m6A signaling
Intramuscular fat (IMF) content is a critical indicator of meat quality in livestock production and possesses significant medical relevance for human health. Betaine, a naturally occurring alkaloid compound, holds considerable potential as a nutritional approach for regulating intramuscular adipogen...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | Animal Nutriomics |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2977377624000267/type/journal_article |
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| _version_ | 1849390911574769664 |
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| author | Jiaqi Liu Tongyudan Yang Yuxi Liu Youhua Liu Yidan Zhu Chaoqun Huang Xinxia Wang |
| author_facet | Jiaqi Liu Tongyudan Yang Yuxi Liu Youhua Liu Yidan Zhu Chaoqun Huang Xinxia Wang |
| author_sort | Jiaqi Liu |
| collection | DOAJ |
| description | Intramuscular fat (IMF) content is a critical indicator of meat quality in livestock production and possesses significant medical relevance for human health. Betaine, a naturally occurring alkaloid compound, holds considerable potential as a nutritional approach for regulating intramuscular adipogenesis, while its exact efficacy and underlying mechanisms still remain subjects of ongoing debate and investigation. Here, we clarified the enhancing effect of betaine on IMF deposition using porcine, murine, and cellular models. Mechanistically, betaine supplementation leads to a significant increase in nicotinamide adenine dinucleotide phosphate (NADPH) concentration in the liver, serum, and skeletal muscle. Elevated levels of NADPH upregulate the expression of fat mass and obesity-associated (FTO), a well-established N6-methyladenosine (m6A) demethylase, to diminish m6A modification in skeletal muscle and IMF deposition. This process effectively promotes the mitotic clonal expansion and subsequently intramuscular adipogenesis. In summary, our findings expand current understanding of the regulatory role of betaine in IMF deposition and sheds light on the molecular mechanisms underlying its modulation, which is conducive to producing high-quality and healthful pork. |
| format | Article |
| id | doaj-art-7bd72248157f4da7bc79011bc6c50608 |
| institution | Kabale University |
| issn | 2977-3776 2977-3784 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Animal Nutriomics |
| spelling | doaj-art-7bd72248157f4da7bc79011bc6c506082025-08-20T03:41:15ZengCambridge University PressAnimal Nutriomics2977-37762977-37842025-01-01210.1017/anr.2024.26Betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving NADPH/FTO/m6A signalingJiaqi Liu0https://orcid.org/0009-0003-8546-7100Tongyudan Yang1Yuxi Liu2Youhua Liu3Yidan Zhu4Chaoqun Huang5Xinxia Wang6College of Animal Sciences, Zhejiang University, Hangzhou, China Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, Hangzhou, China Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, China Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, Hangzhou, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou, China Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, Hangzhou, China Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, China Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, Hangzhou, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou, China Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, Hangzhou, China Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, China Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, Hangzhou, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou, China Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, Hangzhou, China Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, China Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, Hangzhou, ChinaJinhua Academy of Agricultural Sciences, Jinhua, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou, China Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, Hangzhou, China Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, China Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, Hangzhou, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou, China Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, Hangzhou, China Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Hangzhou, China Zhejiang Key Laboratory of nutrition and breeding for high-quality animal products, Hangzhou, ChinaIntramuscular fat (IMF) content is a critical indicator of meat quality in livestock production and possesses significant medical relevance for human health. Betaine, a naturally occurring alkaloid compound, holds considerable potential as a nutritional approach for regulating intramuscular adipogenesis, while its exact efficacy and underlying mechanisms still remain subjects of ongoing debate and investigation. Here, we clarified the enhancing effect of betaine on IMF deposition using porcine, murine, and cellular models. Mechanistically, betaine supplementation leads to a significant increase in nicotinamide adenine dinucleotide phosphate (NADPH) concentration in the liver, serum, and skeletal muscle. Elevated levels of NADPH upregulate the expression of fat mass and obesity-associated (FTO), a well-established N6-methyladenosine (m6A) demethylase, to diminish m6A modification in skeletal muscle and IMF deposition. This process effectively promotes the mitotic clonal expansion and subsequently intramuscular adipogenesis. In summary, our findings expand current understanding of the regulatory role of betaine in IMF deposition and sheds light on the molecular mechanisms underlying its modulation, which is conducive to producing high-quality and healthful pork.https://www.cambridge.org/core/product/identifier/S2977377624000267/type/journal_articlebetaineIMFmeat qualityNADPHm6A modificationMCE |
| spellingShingle | Jiaqi Liu Tongyudan Yang Yuxi Liu Youhua Liu Yidan Zhu Chaoqun Huang Xinxia Wang Betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving NADPH/FTO/m6A signaling Animal Nutriomics betaine IMF meat quality NADPH m6A modification MCE |
| title | Betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving NADPH/FTO/m6A signaling |
| title_full | Betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving NADPH/FTO/m6A signaling |
| title_fullStr | Betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving NADPH/FTO/m6A signaling |
| title_full_unstemmed | Betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving NADPH/FTO/m6A signaling |
| title_short | Betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving NADPH/FTO/m6A signaling |
| title_sort | betaine increases intramuscular fat deposition by promoting the cell cycle via a manner involving nadph fto m6a signaling |
| topic | betaine IMF meat quality NADPH m6A modification MCE |
| url | https://www.cambridge.org/core/product/identifier/S2977377624000267/type/journal_article |
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