Abnormal Liver Function and Blood Coagulation Function of Coronavirus Disease 2019-Infected Pregnant Women
Background: Coronavirus disease 2019 (COVID-19) has been found worldwide since its first outbreak in December 2019. Methods: This study investigated 347 pregnant women at approximately 39 weeks’ gestation from December 2022 to January 2023, which was divided into two groups: COVID-19 positive group...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2023-11-01
|
| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011244 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850220774307135488 |
|---|---|
| author | Wenping Sun Jing Zhang Hongmei Liu |
| author_facet | Wenping Sun Jing Zhang Hongmei Liu |
| author_sort | Wenping Sun |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) has been found worldwide since its first outbreak in December 2019. Methods: This study investigated 347 pregnant women at approximately 39 weeks’ gestation from December 2022 to January 2023, which was divided into two groups: COVID-19 positive group (COVID-19) and COVID-19 negative group (Control). We analyzed blood parameters, liver function, and coagulation parameters of pregnant women with COVID-19 infection and in the Control group. Finally, we divided pregnant women with COVID-19 into two subgroups: No medication (n = 117) and Paracetamol treatment (n = 47), and analyzed effects of paracetamol treatment on the liver and blood coagulation function in COVID-19 infected pregnant women. Results: The alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum total bilirubin (TBIL), total bile acid (TBA), and lactate dehydrogenase (LDH) levels were significantly higher in pregnant women with COVID-19 than that of the control group. Elevated D-dimer, prolonged prothrombin time (PT), activated partial thromboplastin time (APTT), and low levels of fibrinogen (Fib) were observed in patients with COVID-19. There were no significant differences in the liver function between the drug treatment group and no medication group. Conclusions: COVID-19 caused abnormal liver function and blood coagulation function in pregnant women. |
| format | Article |
| id | doaj-art-7bd311460be240f59ee6d2d20f1f57e2 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-7bd311460be240f59ee6d2d20f1f57e22025-08-20T02:06:57ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-11-01501124410.31083/j.ceog5011244S0390-6663(23)02212-1Abnormal Liver Function and Blood Coagulation Function of Coronavirus Disease 2019-Infected Pregnant WomenWenping Sun0Jing Zhang1Hongmei Liu2Department of Obstetrics and Gynecology, Maternity and Child Health Hospital Affiliated with Anhui Medical University, Anhui Province Maternity & Child Health Hospital, 230001 Hefei, Anhui, ChinaDepartment of Obstetrics and Gynecology, Maternity and Child Health Hospital Affiliated with Anhui Medical University, Anhui Province Maternity & Child Health Hospital, 230001 Hefei, Anhui, ChinaDepartment of Obstetrics and Gynecology, Maternity and Child Health Hospital Affiliated with Anhui Medical University, Anhui Province Maternity & Child Health Hospital, 230001 Hefei, Anhui, ChinaBackground: Coronavirus disease 2019 (COVID-19) has been found worldwide since its first outbreak in December 2019. Methods: This study investigated 347 pregnant women at approximately 39 weeks’ gestation from December 2022 to January 2023, which was divided into two groups: COVID-19 positive group (COVID-19) and COVID-19 negative group (Control). We analyzed blood parameters, liver function, and coagulation parameters of pregnant women with COVID-19 infection and in the Control group. Finally, we divided pregnant women with COVID-19 into two subgroups: No medication (n = 117) and Paracetamol treatment (n = 47), and analyzed effects of paracetamol treatment on the liver and blood coagulation function in COVID-19 infected pregnant women. Results: The alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum total bilirubin (TBIL), total bile acid (TBA), and lactate dehydrogenase (LDH) levels were significantly higher in pregnant women with COVID-19 than that of the control group. Elevated D-dimer, prolonged prothrombin time (PT), activated partial thromboplastin time (APTT), and low levels of fibrinogen (Fib) were observed in patients with COVID-19. There were no significant differences in the liver function between the drug treatment group and no medication group. Conclusions: COVID-19 caused abnormal liver function and blood coagulation function in pregnant women.https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011244covid-19liver functioncoagulation functiond-dimer |
| spellingShingle | Wenping Sun Jing Zhang Hongmei Liu Abnormal Liver Function and Blood Coagulation Function of Coronavirus Disease 2019-Infected Pregnant Women Clinical and Experimental Obstetrics & Gynecology covid-19 liver function coagulation function d-dimer |
| title | Abnormal Liver Function and Blood Coagulation Function of Coronavirus Disease 2019-Infected Pregnant Women |
| title_full | Abnormal Liver Function and Blood Coagulation Function of Coronavirus Disease 2019-Infected Pregnant Women |
| title_fullStr | Abnormal Liver Function and Blood Coagulation Function of Coronavirus Disease 2019-Infected Pregnant Women |
| title_full_unstemmed | Abnormal Liver Function and Blood Coagulation Function of Coronavirus Disease 2019-Infected Pregnant Women |
| title_short | Abnormal Liver Function and Blood Coagulation Function of Coronavirus Disease 2019-Infected Pregnant Women |
| title_sort | abnormal liver function and blood coagulation function of coronavirus disease 2019 infected pregnant women |
| topic | covid-19 liver function coagulation function d-dimer |
| url | https://www.imrpress.com/journal/CEOG/50/11/10.31083/j.ceog5011244 |
| work_keys_str_mv | AT wenpingsun abnormalliverfunctionandbloodcoagulationfunctionofcoronavirusdisease2019infectedpregnantwomen AT jingzhang abnormalliverfunctionandbloodcoagulationfunctionofcoronavirusdisease2019infectedpregnantwomen AT hongmeiliu abnormalliverfunctionandbloodcoagulationfunctionofcoronavirusdisease2019infectedpregnantwomen |