Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst
A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using holmium chloride as catalyst. The reactions were performed under solvent free conditions with ultrasound irradiation as the energy sourc...
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| Format: | Article |
| Language: | English |
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University of Tehran
2015-06-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
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| Online Access: | https://jsciences.ut.ac.ir/article_54643_2697fa36306ef65835e2a262449dd2a6.pdf |
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| author | S. Kakaei H. Sid Kalal H. Hoveidi |
| author_facet | S. Kakaei H. Sid Kalal H. Hoveidi |
| author_sort | S. Kakaei |
| collection | DOAJ |
| description | A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using holmium chloride as catalyst. The reactions were performed under solvent free conditions with ultrasound irradiation as the energy source. The advantages of this protocol include the excellent yield, operational simplicity, short time and the avoidance of the use of organic solvents and friendly preparation. Products were identified by mp. and IR, NMR and Mass spectroscopies. |
| format | Article |
| id | doaj-art-7bcdd4a389284ff498e23b18bc7e8086 |
| institution | OA Journals |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-7bcdd4a389284ff498e23b18bc7e80862025-08-20T02:25:54ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69142015-06-0126211712354643Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As CatalystS. Kakaei0H. Sid Kalal1H. Hoveidi21 NFCRS, Nuclear Science and Technology Research Institute, P.O. Box 11365-3486, Tehran, Islamic Republic of Iran1 NFCRS, Nuclear Science and Technology Research Institute, P.O. Box 11365-3486, Tehran, Islamic Republic of Iran2 Graduate Faculty of Environment, University of Tehran, Tehran, Islamic Republic of IranA simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using holmium chloride as catalyst. The reactions were performed under solvent free conditions with ultrasound irradiation as the energy source. The advantages of this protocol include the excellent yield, operational simplicity, short time and the avoidance of the use of organic solvents and friendly preparation. Products were identified by mp. and IR, NMR and Mass spectroscopies.https://jsciences.ut.ac.ir/article_54643_2697fa36306ef65835e2a262449dd2a6.pdfbiginelli reactionsolvent-freeultrasound-assistedone-potholmium chloride |
| spellingShingle | S. Kakaei H. Sid Kalal H. Hoveidi Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst Journal of Sciences, Islamic Republic of Iran biginelli reaction solvent-free ultrasound-assisted one-pot holmium chloride |
| title | Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst |
| title_full | Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst |
| title_fullStr | Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst |
| title_full_unstemmed | Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst |
| title_short | Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst |
| title_sort | ultrasound assisted one pot synthesis of dihydropyrimidinones using holmium chloride as catalyst |
| topic | biginelli reaction solvent-free ultrasound-assisted one-pot holmium chloride |
| url | https://jsciences.ut.ac.ir/article_54643_2697fa36306ef65835e2a262449dd2a6.pdf |
| work_keys_str_mv | AT skakaei ultrasoundassistedonepotsynthesisofdihydropyrimidinonesusingholmiumchlorideascatalyst AT hsidkalal ultrasoundassistedonepotsynthesisofdihydropyrimidinonesusingholmiumchlorideascatalyst AT hhoveidi ultrasoundassistedonepotsynthesisofdihydropyrimidinonesusingholmiumchlorideascatalyst |