Ultrasound Assisted One-pot Synthesis of Dihydropyrimidinones Using Holmium Chloride As Catalyst
A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using holmium chloride as catalyst. The reactions were performed under solvent free conditions with ultrasound irradiation as the energy sourc...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Tehran
2015-06-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Subjects: | |
| Online Access: | https://jsciences.ut.ac.ir/article_54643_2697fa36306ef65835e2a262449dd2a6.pdf |
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| Summary: | A simple and green chemical procedure was reported for the synthesis of dihydropyrimidinones from various aldehydes, ethyl acetoacetate and urea or thiourea using holmium chloride as catalyst. The reactions were performed under solvent free conditions with ultrasound irradiation as the energy source. The advantages of this protocol include the excellent yield, operational simplicity, short time and the avoidance of the use of organic solvents and friendly preparation. Products were identified by mp. and IR, NMR and Mass spectroscopies. |
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| ISSN: | 1016-1104 2345-6914 |