Evaluation of the antibacterial activity of CuO and ZnO nanoparticles against uropathogenic Escherichia coli
E. coli responsible for urinary tract infections (UTI) became resistant to obtainable therapies. So, nanotechnology appears currently as promising innovation among various strategies under development. In the present study we evaluate the antimicrobial effects of CuO and ZnO nanoparticles against E....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Taibah University for Science |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16583655.2024.2322776 |
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| author | Hanan M. Abbas Mohammed F. Al Marjani Radhouane Gdoura |
| author_facet | Hanan M. Abbas Mohammed F. Al Marjani Radhouane Gdoura |
| author_sort | Hanan M. Abbas |
| collection | DOAJ |
| description | E. coli responsible for urinary tract infections (UTI) became resistant to obtainable therapies. So, nanotechnology appears currently as promising innovation among various strategies under development. In the present study we evaluate the antimicrobial effects of CuO and ZnO nanoparticles against E. coli isolated from UTI. Biofilm production and expression of quorum sensing genes luxS and motA were performed on E. coli treated with the nanoparticles. luxS and motA genes were detected in the tested E. coli. All isolates produced strong, moderate and weak biofilm. All isolates had a weak biofilm formation and decreased gene expression for luxS and motA genes after treatment with CuO, ZnO and their mixture. Besides, CuO and ZnO had non-toxic effects on Human Dermal Fibroblasts and neonatal normal cells. In conclusion, the mixture of CuO and ZnO had a role in decreasing the gene expression of luxS and motA genes more than each alone. |
| format | Article |
| id | doaj-art-7bcd7da5b0844597a2b4818a81497097 |
| institution | OA Journals |
| issn | 1658-3655 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj-art-7bcd7da5b0844597a2b4818a814970972025-08-20T02:36:43ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552024-12-0118110.1080/16583655.2024.2322776Evaluation of the antibacterial activity of CuO and ZnO nanoparticles against uropathogenic Escherichia coliHanan M. Abbas0Mohammed F. Al Marjani1Radhouane Gdoura2Research Laboratory of Toxicology Microbiology Environmental and Health, Faculty of Sciences, Sfax University, Sfax, TunisiaCollage of Science, Mustansiriyah University, Baghdad, IraqResearch Laboratory of Toxicology Microbiology Environmental and Health, Faculty of Sciences, Sfax University, Sfax, TunisiaE. coli responsible for urinary tract infections (UTI) became resistant to obtainable therapies. So, nanotechnology appears currently as promising innovation among various strategies under development. In the present study we evaluate the antimicrobial effects of CuO and ZnO nanoparticles against E. coli isolated from UTI. Biofilm production and expression of quorum sensing genes luxS and motA were performed on E. coli treated with the nanoparticles. luxS and motA genes were detected in the tested E. coli. All isolates produced strong, moderate and weak biofilm. All isolates had a weak biofilm formation and decreased gene expression for luxS and motA genes after treatment with CuO, ZnO and their mixture. Besides, CuO and ZnO had non-toxic effects on Human Dermal Fibroblasts and neonatal normal cells. In conclusion, the mixture of CuO and ZnO had a role in decreasing the gene expression of luxS and motA genes more than each alone.https://www.tandfonline.com/doi/10.1080/16583655.2024.2322776E. coli; CuOZnOnanoparticlesurinary infection |
| spellingShingle | Hanan M. Abbas Mohammed F. Al Marjani Radhouane Gdoura Evaluation of the antibacterial activity of CuO and ZnO nanoparticles against uropathogenic Escherichia coli Journal of Taibah University for Science E. coli; CuO ZnO nanoparticles urinary infection |
| title | Evaluation of the antibacterial activity of CuO and ZnO nanoparticles against uropathogenic Escherichia coli |
| title_full | Evaluation of the antibacterial activity of CuO and ZnO nanoparticles against uropathogenic Escherichia coli |
| title_fullStr | Evaluation of the antibacterial activity of CuO and ZnO nanoparticles against uropathogenic Escherichia coli |
| title_full_unstemmed | Evaluation of the antibacterial activity of CuO and ZnO nanoparticles against uropathogenic Escherichia coli |
| title_short | Evaluation of the antibacterial activity of CuO and ZnO nanoparticles against uropathogenic Escherichia coli |
| title_sort | evaluation of the antibacterial activity of cuo and zno nanoparticles against uropathogenic escherichia coli |
| topic | E. coli; CuO ZnO nanoparticles urinary infection |
| url | https://www.tandfonline.com/doi/10.1080/16583655.2024.2322776 |
| work_keys_str_mv | AT hananmabbas evaluationoftheantibacterialactivityofcuoandznonanoparticlesagainsturopathogenicescherichiacoli AT mohammedfalmarjani evaluationoftheantibacterialactivityofcuoandznonanoparticlesagainsturopathogenicescherichiacoli AT radhouanegdoura evaluationoftheantibacterialactivityofcuoandznonanoparticlesagainsturopathogenicescherichiacoli |