Large‐cell neuroendocrine carcinoma of the kidney effectively treated by nivolumab and ipilimumab
Introduction Neuroendocrine tumors originating in the kidney are rare, and standard treatments are not established. Case presentation An 80‐years‐old man was referred to our hospital with renal dysfunction and a left renal mass. Based on CT and bone scintigraphy results, he was diagnosed as having a...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
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| Series: | IJU Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iju5.12798 |
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| Summary: | Introduction Neuroendocrine tumors originating in the kidney are rare, and standard treatments are not established. Case presentation An 80‐years‐old man was referred to our hospital with renal dysfunction and a left renal mass. Based on CT and bone scintigraphy results, he was diagnosed as having a large left renal tumor with a thrombus in the inferior vena cava, harboring lymph node, liver, lung, and left iliac bone metastasis. The renal biopsy indicated a large‐cell neuroendocrine carcinoma. Treatment with nivolumab + ipilimumab was introduced. The local and metastatic tumors had shrunk. Subsequently, treatment with nivolumab has remained effective for >2 years. Conclusion This case demonstrates the efficacy of treatment with the immune‐checkpoint inhibitors against large‐cell neuroendocrine carcinoma of the kidney. |
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| ISSN: | 2577-171X |