The Predictive Factors in Preschool Wheezers for Subsequent Asthma Hospitalization after the Age of 6 Years
Background: Preschool children with wheeze may develop asthma later at school age. Positive skin prick test (SPT) to common aeroallergens in preschool wheezers may be associated with a higher chance of developing asthma at school age. Methods: All patients with SPT performed for the indication of pr...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Pediatric Respirology and Critical Care Medicine |
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| Online Access: | https://journals.lww.com/10.4103/prcm.prcm_15_16 |
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| author | Pui-Tak Yu Johnny Yick-Chun Chan Freddie Poon Rachel Shui-Ping Lee Shuk-Yu Leung Jonathan Pak-Heng Ng Ka-Ka Siu Ada Yuen-Fong Yip Ka-Li Kwok Eric Yat-Tung Chan Jeff Chin-Pang Wong Daniel Kwok-Keung Ng |
| author_facet | Pui-Tak Yu Johnny Yick-Chun Chan Freddie Poon Rachel Shui-Ping Lee Shuk-Yu Leung Jonathan Pak-Heng Ng Ka-Ka Siu Ada Yuen-Fong Yip Ka-Li Kwok Eric Yat-Tung Chan Jeff Chin-Pang Wong Daniel Kwok-Keung Ng |
| author_sort | Pui-Tak Yu |
| collection | DOAJ |
| description | Background:
Preschool children with wheeze may develop asthma later at school age. Positive skin prick test (SPT) to common aeroallergens in preschool wheezers may be associated with a higher chance of developing asthma at school age.
Methods:
All patients with SPT performed for the indication of preschool wheeze, i.e., before the age of 6 years, were included in the study from 1999 to 2011. Outcome measures including asthmatic attack requiring emergency hospitalization and the need for asthma controller prescription after the age of 6 years were retrieved from the hospital database. Potential risk factors including gender, family history of asthma, blood eosinophilia, environmental tobacco exposure, personal eczema, and allergic rhinitis were also retrieved for analysis. Multiple logistic regression was performed to identify independent risk factors.
Results:
Altogether, 463 children were included for analysis with mean age at SPT of 3.1 ± 1.36 years and 64.6% were male. Positive SPT results were obtained in 60.5% of patients. For preschool children with wheeze, female gender (odds ratio [OR] = 1.90, 95% confidence interval [CI]: 1.04–3.46, P = 0.036), positive SPT (OR = 2.96, 95% CI: 1.40–6.24, P = 0.004), and late-onset preschool wheeze hospitalization (OR = 2.82, 95% CI: 1.42–5.61, P = 0.003) were associated with a higher chance of asthmatic hospitalization after the age of 6 years. Allergic rhinitis (OR = 4.58, 95% CI: 2.16–9.71, P < 0.001) and family history of asthma (OR = 1.82, 95% CI: 1.09–3.02, P = 0.022) were associated with higher chance for asthma controller prescription.
Conclusion:
For preschool wheeze, female gender, positive SPT, and late-onset preschool wheeze index are associated with a higher chance of asthmatic hospitalization after the age of 6 years while allergic rhinitis and family history of asthma are associated with a higher chance for asthma controller prescription after the age of 6 years. |
| format | Article |
| id | doaj-art-7bc956d2ae8945fa814410d8bfe25673 |
| institution | OA Journals |
| issn | 2543-0343 2543-0351 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Pediatric Respirology and Critical Care Medicine |
| spelling | doaj-art-7bc956d2ae8945fa814410d8bfe256732025-08-20T01:47:48ZengWolters Kluwer Medknow PublicationsPediatric Respirology and Critical Care Medicine2543-03432543-03512017-01-0111111610.4103/prcm.prcm_15_16The Predictive Factors in Preschool Wheezers for Subsequent Asthma Hospitalization after the Age of 6 YearsPui-Tak YuJohnny Yick-Chun ChanFreddie PoonRachel Shui-Ping LeeShuk-Yu LeungJonathan Pak-Heng NgKa-Ka SiuAda Yuen-Fong YipKa-Li KwokEric Yat-Tung ChanJeff Chin-Pang WongDaniel Kwok-Keung NgBackground: Preschool children with wheeze may develop asthma later at school age. Positive skin prick test (SPT) to common aeroallergens in preschool wheezers may be associated with a higher chance of developing asthma at school age. Methods: All patients with SPT performed for the indication of preschool wheeze, i.e., before the age of 6 years, were included in the study from 1999 to 2011. Outcome measures including asthmatic attack requiring emergency hospitalization and the need for asthma controller prescription after the age of 6 years were retrieved from the hospital database. Potential risk factors including gender, family history of asthma, blood eosinophilia, environmental tobacco exposure, personal eczema, and allergic rhinitis were also retrieved for analysis. Multiple logistic regression was performed to identify independent risk factors. Results: Altogether, 463 children were included for analysis with mean age at SPT of 3.1 ± 1.36 years and 64.6% were male. Positive SPT results were obtained in 60.5% of patients. For preschool children with wheeze, female gender (odds ratio [OR] = 1.90, 95% confidence interval [CI]: 1.04–3.46, P = 0.036), positive SPT (OR = 2.96, 95% CI: 1.40–6.24, P = 0.004), and late-onset preschool wheeze hospitalization (OR = 2.82, 95% CI: 1.42–5.61, P = 0.003) were associated with a higher chance of asthmatic hospitalization after the age of 6 years. Allergic rhinitis (OR = 4.58, 95% CI: 2.16–9.71, P < 0.001) and family history of asthma (OR = 1.82, 95% CI: 1.09–3.02, P = 0.022) were associated with higher chance for asthma controller prescription. Conclusion: For preschool wheeze, female gender, positive SPT, and late-onset preschool wheeze index are associated with a higher chance of asthmatic hospitalization after the age of 6 years while allergic rhinitis and family history of asthma are associated with a higher chance for asthma controller prescription after the age of 6 years.https://journals.lww.com/10.4103/prcm.prcm_15_16allergensasthmachild |
| spellingShingle | Pui-Tak Yu Johnny Yick-Chun Chan Freddie Poon Rachel Shui-Ping Lee Shuk-Yu Leung Jonathan Pak-Heng Ng Ka-Ka Siu Ada Yuen-Fong Yip Ka-Li Kwok Eric Yat-Tung Chan Jeff Chin-Pang Wong Daniel Kwok-Keung Ng The Predictive Factors in Preschool Wheezers for Subsequent Asthma Hospitalization after the Age of 6 Years Pediatric Respirology and Critical Care Medicine allergens asthma child |
| title | The Predictive Factors in Preschool Wheezers for Subsequent Asthma Hospitalization after the Age of 6 Years |
| title_full | The Predictive Factors in Preschool Wheezers for Subsequent Asthma Hospitalization after the Age of 6 Years |
| title_fullStr | The Predictive Factors in Preschool Wheezers for Subsequent Asthma Hospitalization after the Age of 6 Years |
| title_full_unstemmed | The Predictive Factors in Preschool Wheezers for Subsequent Asthma Hospitalization after the Age of 6 Years |
| title_short | The Predictive Factors in Preschool Wheezers for Subsequent Asthma Hospitalization after the Age of 6 Years |
| title_sort | predictive factors in preschool wheezers for subsequent asthma hospitalization after the age of 6 years |
| topic | allergens asthma child |
| url | https://journals.lww.com/10.4103/prcm.prcm_15_16 |
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