Difference between early clinical features of swine origin A H1N1 influenza corfirmed and not confirmed infection in Mexico
Introduction: The Swine Origin A H1N1 Influenza Virus (SOIV) pandemic emerged in April 2009 affecting people and health-care systems worldwide. This study examined the differences among the early clinical features presented in confirmed SOIV cases, those who tested negative for SOIV infection, fata...
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The Journal of Infection in Developing Countries
2011-11-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1599 |
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| author | Monica Rodríguez-Valero Hector Manuel Prado Calleros Gerardo Arturo Bravo Escobar Rafael Ricardo Valdez Vázquez Rafael Figueroa Moreno Guillermo Martínez Montes Simón Kawa Karasik |
| author_facet | Monica Rodríguez-Valero Hector Manuel Prado Calleros Gerardo Arturo Bravo Escobar Rafael Ricardo Valdez Vázquez Rafael Figueroa Moreno Guillermo Martínez Montes Simón Kawa Karasik |
| author_sort | Monica Rodríguez-Valero |
| collection | DOAJ |
| description |
Introduction: The Swine Origin A H1N1 Influenza Virus (SOIV) pandemic emerged in April 2009 affecting people and health-care systems worldwide. This study examined the differences among the early clinical features presented in confirmed SOIV cases, those who tested negative for SOIV infection, fatalities, and hospitalized cases.
Methodology: We reviewed 1,024 initial medical records of patients presenting with acute respiratory symptoms who attended the respiratory emergency room of a general hospital in Mexico and had a confirmatory test for influenza AH1N1 by RT-PCR from April to December 2009.
Results: Out of 1,024 cases, 457 (44%) were men with a mean age of 31±17 years; however, of these, SOIV confirmed cases were younger (26±8, p=0.000). SOIV infection was confirmed in 36% of the patients. Most (%?) cases presented mild infection, 20% of the patients required hospitalization, and 0.09% patients died. Asthma was more frequent in confirmed cases (p=0.028). Presence of COPD, systemic arterial hypertension, and diabetes mellitus was significant in confirmed hospitalized cases. Pulmonary rales, wheezing, and sudden symptom onset were more frequent and statistically significant in confirmed patients. Influenza-like illness was more frequent in confirmed cases (p=0.049).
Conclusions: This study presents one of the largest series of the new SOIV infection confirmed by RT-PCR reported. This infection is frequently mild and affects mainly young adults. Sudden symptoms onset, pulmonary rales, and wheezing are early features of this infection. Asthma, COPD, systemic arterial hypertension, and diabetes mellitus should be identified to identify potentially severe and fatal cases. ILI helps distinguish SOIV infection.
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| format | Article |
| id | doaj-art-7bc72b794d3b4b608e9961033b1fdea2 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-11-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-7bc72b794d3b4b608e9961033b1fdea22025-08-20T02:16:14ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-11-0160410.3855/jidc.1599Difference between early clinical features of swine origin A H1N1 influenza corfirmed and not confirmed infection in MexicoMonica Rodríguez-Valero0Hector Manuel Prado Calleros1Gerardo Arturo Bravo Escobar2Rafael Ricardo Valdez Vázquez3Rafael Figueroa Moreno4Guillermo Martínez Montes5Simón Kawa Karasik6Otorhinolaryngology Division, Hospital General Dr Manuel Gea Gonzalez, Mexico City, MexicoOtorhinolaryngology Division, Hospital General Dr Manuel Gea Gonzalez, Mexico City, MexicoOtorhinolaryngology Division, Hospital General Dr Manuel Gea Gonzalez, Mexico City, MexicoEpidemiology Subdirector, Hospital General Dr Manuel Gea Gonzalez, Mexico City, MexicoClinical Epidemiology and Preventive Medicine Division, Hospital General Dr Manuel Gea Gonzalez, Mexico City, MexicoOtorhinolaryngology Division, Hospital General Dr Manuel Gea Gonzalez, Mexico City, MexicoNational Bioethics Commission, Mexico City, Mexico Introduction: The Swine Origin A H1N1 Influenza Virus (SOIV) pandemic emerged in April 2009 affecting people and health-care systems worldwide. This study examined the differences among the early clinical features presented in confirmed SOIV cases, those who tested negative for SOIV infection, fatalities, and hospitalized cases. Methodology: We reviewed 1,024 initial medical records of patients presenting with acute respiratory symptoms who attended the respiratory emergency room of a general hospital in Mexico and had a confirmatory test for influenza AH1N1 by RT-PCR from April to December 2009. Results: Out of 1,024 cases, 457 (44%) were men with a mean age of 31±17 years; however, of these, SOIV confirmed cases were younger (26±8, p=0.000). SOIV infection was confirmed in 36% of the patients. Most (%?) cases presented mild infection, 20% of the patients required hospitalization, and 0.09% patients died. Asthma was more frequent in confirmed cases (p=0.028). Presence of COPD, systemic arterial hypertension, and diabetes mellitus was significant in confirmed hospitalized cases. Pulmonary rales, wheezing, and sudden symptom onset were more frequent and statistically significant in confirmed patients. Influenza-like illness was more frequent in confirmed cases (p=0.049). Conclusions: This study presents one of the largest series of the new SOIV infection confirmed by RT-PCR reported. This infection is frequently mild and affects mainly young adults. Sudden symptoms onset, pulmonary rales, and wheezing are early features of this infection. Asthma, COPD, systemic arterial hypertension, and diabetes mellitus should be identified to identify potentially severe and fatal cases. ILI helps distinguish SOIV infection. https://jidc.org/index.php/journal/article/view/1599Swine Origin Influenza Virus A H1N1influenzafluInfluenza A H1N1influenza A/Mexico/2009 (H1N1) |
| spellingShingle | Monica Rodríguez-Valero Hector Manuel Prado Calleros Gerardo Arturo Bravo Escobar Rafael Ricardo Valdez Vázquez Rafael Figueroa Moreno Guillermo Martínez Montes Simón Kawa Karasik Difference between early clinical features of swine origin A H1N1 influenza corfirmed and not confirmed infection in Mexico Journal of Infection in Developing Countries Swine Origin Influenza Virus A H1N1 influenza flu Influenza A H1N1 influenza A/Mexico/2009 (H1N1) |
| title | Difference between early clinical features of swine origin A H1N1 influenza corfirmed and not confirmed infection in Mexico |
| title_full | Difference between early clinical features of swine origin A H1N1 influenza corfirmed and not confirmed infection in Mexico |
| title_fullStr | Difference between early clinical features of swine origin A H1N1 influenza corfirmed and not confirmed infection in Mexico |
| title_full_unstemmed | Difference between early clinical features of swine origin A H1N1 influenza corfirmed and not confirmed infection in Mexico |
| title_short | Difference between early clinical features of swine origin A H1N1 influenza corfirmed and not confirmed infection in Mexico |
| title_sort | difference between early clinical features of swine origin a h1n1 influenza corfirmed and not confirmed infection in mexico |
| topic | Swine Origin Influenza Virus A H1N1 influenza flu Influenza A H1N1 influenza A/Mexico/2009 (H1N1) |
| url | https://jidc.org/index.php/journal/article/view/1599 |
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