Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in Benin
Abstract Background The implementation of the WHO’s 2015 recommendations in Benin, requires an assessment of the progress made over time in preventing the transmission of the infection to exposed-infants, and the identification of its determinants. Methods This was a retrospective study of HIV-1 exp...
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BMC
2024-10-01
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| Online Access: | https://doi.org/10.1186/s12887-024-05131-0 |
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| author | Edwige Hermione Dagba Gbessin Haziz Sina René Kpemahouton Keke Michel Kiréopori Gomgnimbou Aldric Afangnihoun Moussa Bachabi Abdoul-Salam Ouedraogo Lamine Baba-Moussa |
| author_facet | Edwige Hermione Dagba Gbessin Haziz Sina René Kpemahouton Keke Michel Kiréopori Gomgnimbou Aldric Afangnihoun Moussa Bachabi Abdoul-Salam Ouedraogo Lamine Baba-Moussa |
| author_sort | Edwige Hermione Dagba Gbessin |
| collection | DOAJ |
| description | Abstract Background The implementation of the WHO’s 2015 recommendations in Benin, requires an assessment of the progress made over time in preventing the transmission of the infection to exposed-infants, and the identification of its determinants. Methods This was a retrospective study of HIV-1 exposed-infants who underwent PCR between the 6th and 8th weeks of life. Early diagnostic tests were performed using the Abbott m2000 RealTime platform. Comparison of proportions tests (analysis of the significance of the difference in prevalence) with an error threshold of 5% were used to assess the determinants of the transmission. Statistical analysis was performed using R statistical software, version 4.1.3.0. Results A total of 5,312 infants benefited from early diagnosis by PCR between 2016 and 2021. Among them, 52% are males, tritherapy before pregnancy was the majority treatment used by mothers (30.6%) and monotherapy that of newborns (70%). Mixed breastfeeding is the feeding method with the highest prevalence. The overall transmission rate was 3.4% over the six years. The highest prevalence was achieved in 2018 (4.2%) and the lowest in 2021 (2.7%). The prevalence was lower when mothers were on tritherapy before pregnancy. The determinants of transmission were: mixed breastfeeding, lack of treatment in mothers (22.4%), lack of treatment in infants (19.7%), undefined treatments or absence of treatment in the mother-child pair. Conclusion This study shows the contribution over time of the PMTCT program to reducing HIV transmission among exposed-infants and also underlines the need for proper conduct of treatment in any women of childbearing age. |
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| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
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| series | BMC Pediatrics |
| spelling | doaj-art-7bc2ee31d43d47c2be0819fef0452afa2025-08-20T02:17:56ZengBMCBMC Pediatrics1471-24312024-10-012411710.1186/s12887-024-05131-0Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in BeninEdwige Hermione Dagba Gbessin0Haziz Sina1René Kpemahouton Keke2Michel Kiréopori Gomgnimbou3Aldric Afangnihoun4Moussa Bachabi5Abdoul-Salam Ouedraogo6Lamine Baba-Moussa7NAZI BONI UniversityLaboratory of Biology and Molecular Typing in Microbiology (LBTMM), Faculty of Sciences and Technology (FAST), University of Abomey - CalaviNational Reference Laboratory of Health Program Fighting Against AIDS in Benin (NRL/PSLS), Health Ministry of BeninMolecular Biology Laboratory, Muraz Center, Higher Institute of Health Sciences (INSSA), Nazi Boni UniversityHealth Program Fighting Against AIDS in Benin (PSLS), Health Ministry of BeninHealth Program Fighting Against AIDS in Benin (PSLS), Health Ministry of BeninLaboratory of Emerging and Re-emerging Pathogens (LaPathER), Doctoral School of Health Sciences, Nazi BONI UniversityLaboratory of Biology and Molecular Typing in Microbiology (LBTMM), Faculty of Sciences and Technology (FAST), University of Abomey - CalaviAbstract Background The implementation of the WHO’s 2015 recommendations in Benin, requires an assessment of the progress made over time in preventing the transmission of the infection to exposed-infants, and the identification of its determinants. Methods This was a retrospective study of HIV-1 exposed-infants who underwent PCR between the 6th and 8th weeks of life. Early diagnostic tests were performed using the Abbott m2000 RealTime platform. Comparison of proportions tests (analysis of the significance of the difference in prevalence) with an error threshold of 5% were used to assess the determinants of the transmission. Statistical analysis was performed using R statistical software, version 4.1.3.0. Results A total of 5,312 infants benefited from early diagnosis by PCR between 2016 and 2021. Among them, 52% are males, tritherapy before pregnancy was the majority treatment used by mothers (30.6%) and monotherapy that of newborns (70%). Mixed breastfeeding is the feeding method with the highest prevalence. The overall transmission rate was 3.4% over the six years. The highest prevalence was achieved in 2018 (4.2%) and the lowest in 2021 (2.7%). The prevalence was lower when mothers were on tritherapy before pregnancy. The determinants of transmission were: mixed breastfeeding, lack of treatment in mothers (22.4%), lack of treatment in infants (19.7%), undefined treatments or absence of treatment in the mother-child pair. Conclusion This study shows the contribution over time of the PMTCT program to reducing HIV transmission among exposed-infants and also underlines the need for proper conduct of treatment in any women of childbearing age.https://doi.org/10.1186/s12887-024-05131-0Benin – PMTCT – HIVEarly diagnosisTransmission rate |
| spellingShingle | Edwige Hermione Dagba Gbessin Haziz Sina René Kpemahouton Keke Michel Kiréopori Gomgnimbou Aldric Afangnihoun Moussa Bachabi Abdoul-Salam Ouedraogo Lamine Baba-Moussa Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in Benin BMC Pediatrics Benin – PMTCT – HIV Early diagnosis Transmission rate |
| title | Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in Benin |
| title_full | Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in Benin |
| title_fullStr | Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in Benin |
| title_full_unstemmed | Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in Benin |
| title_short | Residual transmission of HIV infection from mother to child in the Atlantic and littoral departments in Benin |
| title_sort | residual transmission of hiv infection from mother to child in the atlantic and littoral departments in benin |
| topic | Benin – PMTCT – HIV Early diagnosis Transmission rate |
| url | https://doi.org/10.1186/s12887-024-05131-0 |
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