Preclinical efficacy and safety evaluation of BD211 autologous CD34+ hematopoietic stem cell injection for transfusion-dependent β-thalassemia in NCG-X mice

Preclinical efficacy and safety evaluation of BD211 autologous CD34+ hematopoietic stem cell injection for transfusion-dependent β-thalassemia in NCG-X mice

IntroductionAutologous CD34+ hematopoietic stem cell-based therapies have shown promise in addressing therapeutic needs. However, a comprehensive evaluation of their efficacy and safety is crucial before clinical application. This study aimed to assess the efficacy and safety profile of BD211 autolo...

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Bibliographic Details
Main Authors: Xuedong Dai, Zike Li, Shuang Chen, Ying Huang, Sikai Ling, Quanjun Wang, Qi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
transfusion-dependent β-thalassemia
BD211
NCG-X mice
no-observed-adverseeffect level
toxicokinetic
distribution
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1607707/full
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