Acute Kidney Injury After the Concurrent Use of Checkpoint Inhibitors and Proton Pump Inhibitors
As the use of immune checkpoint inhibitors (CPIs) in cancer treatment has increased, so has the number of immune-related adverse events (irAEs), such as acute kidney injury (AKI). Proton pump inhibitors (PPIs) have also been associated with AKI, but PPIs are still consistently prescribed for acid re...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-02-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0122 |
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| author | Helen I. Gandler Niveditha Badrinarayanan Anthony E. Calderon Pamela C. Gibson Nina Narasimhadevara Marios C. Prikis |
| author_facet | Helen I. Gandler Niveditha Badrinarayanan Anthony E. Calderon Pamela C. Gibson Nina Narasimhadevara Marios C. Prikis |
| author_sort | Helen I. Gandler |
| collection | DOAJ |
| description | As the use of immune checkpoint inhibitors (CPIs) in cancer treatment has increased, so has the number of immune-related adverse events (irAEs), such as acute kidney injury (AKI). Proton pump inhibitors (PPIs) have also been associated with AKI, but PPIs are still consistently prescribed for acid reflux and are often administered to patients also receiving CPI therapy. We describe 3 patients who were each receiving both a CPI and PPI and had an AKI within 5 months of concurrent therapy. This suggests that clinicians should be cautious about prescribing CPIs in conjunction with PPIs. |
| format | Article |
| id | doaj-art-7bc06a1a4c764bc8ad5d66553ff15fc5 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-7bc06a1a4c764bc8ad5d66553ff15fc52025-08-20T02:11:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-02-013210.7326/aimcc.2023.0122Acute Kidney Injury After the Concurrent Use of Checkpoint Inhibitors and Proton Pump InhibitorsHelen I. Gandler0Niveditha Badrinarayanan1Anthony E. Calderon2Pamela C. Gibson3Nina Narasimhadevara4Marios C. Prikis51Larner College of Medicine at the University of Vermont, Burlington, Vermont1Larner College of Medicine at the University of Vermont, Burlington, Vermont2UVMMC Specialty Pharmacy, Burlington, Vermont3Department of Pathology, Larner College of Medicine at the University of Vermont, Burlington, Vermont4Division of Nephrology and Transplantation, Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont4Division of Nephrology and Transplantation, Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VermontAs the use of immune checkpoint inhibitors (CPIs) in cancer treatment has increased, so has the number of immune-related adverse events (irAEs), such as acute kidney injury (AKI). Proton pump inhibitors (PPIs) have also been associated with AKI, but PPIs are still consistently prescribed for acid reflux and are often administered to patients also receiving CPI therapy. We describe 3 patients who were each receiving both a CPI and PPI and had an AKI within 5 months of concurrent therapy. This suggests that clinicians should be cautious about prescribing CPIs in conjunction with PPIs.https://www.acpjournals.org/doi/10.7326/aimcc.2023.0122 |
| spellingShingle | Helen I. Gandler Niveditha Badrinarayanan Anthony E. Calderon Pamela C. Gibson Nina Narasimhadevara Marios C. Prikis Acute Kidney Injury After the Concurrent Use of Checkpoint Inhibitors and Proton Pump Inhibitors Annals of Internal Medicine: Clinical Cases |
| title | Acute Kidney Injury After the Concurrent Use of Checkpoint Inhibitors and Proton Pump Inhibitors |
| title_full | Acute Kidney Injury After the Concurrent Use of Checkpoint Inhibitors and Proton Pump Inhibitors |
| title_fullStr | Acute Kidney Injury After the Concurrent Use of Checkpoint Inhibitors and Proton Pump Inhibitors |
| title_full_unstemmed | Acute Kidney Injury After the Concurrent Use of Checkpoint Inhibitors and Proton Pump Inhibitors |
| title_short | Acute Kidney Injury After the Concurrent Use of Checkpoint Inhibitors and Proton Pump Inhibitors |
| title_sort | acute kidney injury after the concurrent use of checkpoint inhibitors and proton pump inhibitors |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0122 |
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