Outer membrane vesicles of Porphyromonas gingivalis impede bone regeneration by inducing ferroptosis via the Hippo-YAP signaling pathway

Outer membrane vesicles of Porphyromonas gingivalis impede bone regeneration by inducing ferroptosis via the Hippo-YAP signaling pathway

Abstract Background Although increasing evidence confirms that oral microbiota imbalance is a critical factor inhibiting bone regeneration, the specific mechanisms have remained unexplored. This study aims to use periodontitis as a model of oral microbiota imbalance to investigate the specific mecha...

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Bibliographic Details
Main Authors: Xinghong Luo, Yanzhen Wang, Tingting Ning, Qian Lei, Hao Cui, Xianghui Zou, Yan Chen, Shuoling Chen, Xinyao Zhang, Shenglong Tan, Dandan Ma
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Oral microbiota imbalance
OMVs
BMSCs
Bone regeneration
Ferroptosis
Online Access:https://doi.org/10.1186/s12951-025-03457-0
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