Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice
The hippocampus is the brain structure that is responsible for the formation of learning memories. Sleep disorders leading to cognitive impairment are strongly associated with the hippocampus. Phototherapy offers a new physical therapy for the treatment of sleep disorders, with the advantages of bei...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2025-03-01
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| Series: | Journal of Innovative Optical Health Sciences |
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| Online Access: | https://www.worldscientific.com/doi/10.1142/S1793545825500014 |
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| author | Na Li Xuechun Li Zhongdi Jiang Xiafei Shi Huancheng Wu Yi Liu Huijuan Yin Hongli Chen |
| author_facet | Na Li Xuechun Li Zhongdi Jiang Xiafei Shi Huancheng Wu Yi Liu Huijuan Yin Hongli Chen |
| author_sort | Na Li |
| collection | DOAJ |
| description | The hippocampus is the brain structure that is responsible for the formation of learning memories. Sleep disorders leading to cognitive impairment are strongly associated with the hippocampus. Phototherapy offers a new physical therapy for the treatment of sleep disorders, with the advantages of being noninvasive and having few side effects. However, the mechanism by which phototherapy improves cognitive impairment caused by sleep disorders remains unclear. In this study, we used phototherapy combined with optogenetic technology to investigate the effect of noninvasive phototherapy on cognitive functions in sleep-deprived mice. Our results suggest that phototherapy might improve cognitive functions in sleep-deprived mice by modulating the hippocampus. Our study expands the research progress on noninvasive phototherapy for the treatment of sleep disorders. |
| format | Article |
| id | doaj-art-7bb695947d6848cbb1f1eafebbfcf1ce |
| institution | Kabale University |
| issn | 1793-5458 1793-7205 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj-art-7bb695947d6848cbb1f1eafebbfcf1ce2025-08-20T03:42:02ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052025-03-01180210.1142/S1793545825500014Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived miceNa Li0Xuechun Li1Zhongdi Jiang2Xiafei Shi3Huancheng Wu4Yi Liu5Huijuan Yin6Hongli Chen7State Key Laboratory of Advanced Medical Materials and Devices, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, P. R. ChinaState Key Laboratory of Separation Membranes and Membrane Processes & Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes, Tianjin Key Laboratory of Optoelectronic Detection Technology and Systems, School of Life Sciences, Tiangong University Tianjin 300387, P. R. ChinaState Key Laboratory of Separation Membranes and Membrane Processes & Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes, Tianjin Key Laboratory of Optoelectronic Detection Technology and Systems, School of Life Sciences, Tiangong University Tianjin 300387, P. R. ChinaState Key Laboratory of Separation Membranes and Membrane Processes & Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes, Tianjin Key Laboratory of Optoelectronic Detection Technology and Systems, School of Life Sciences, Tiangong University Tianjin 300387, P. R. ChinaDepartment of Neurosurgery, Tianjin Beichen Hospital, Tianjin 300400, P. R. ChinaState Key Laboratory of Separation Membranes and Membrane Processes & Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes, Tianjin Key Laboratory of Optoelectronic Detection Technology and Systems, School of Life Sciences, Tiangong University Tianjin 300387, P. R. ChinaState Key Laboratory of Advanced Medical Materials and Devices, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, P. R. ChinaState Key Laboratory of Advanced Medical Materials and Devices, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, P. R. ChinaThe hippocampus is the brain structure that is responsible for the formation of learning memories. Sleep disorders leading to cognitive impairment are strongly associated with the hippocampus. Phototherapy offers a new physical therapy for the treatment of sleep disorders, with the advantages of being noninvasive and having few side effects. However, the mechanism by which phototherapy improves cognitive impairment caused by sleep disorders remains unclear. In this study, we used phototherapy combined with optogenetic technology to investigate the effect of noninvasive phototherapy on cognitive functions in sleep-deprived mice. Our results suggest that phototherapy might improve cognitive functions in sleep-deprived mice by modulating the hippocampus. Our study expands the research progress on noninvasive phototherapy for the treatment of sleep disorders.https://www.worldscientific.com/doi/10.1142/S1793545825500014Phototherapyphotobiomodulationoptogeneticsleep deprivation |
| spellingShingle | Na Li Xuechun Li Zhongdi Jiang Xiafei Shi Huancheng Wu Yi Liu Huijuan Yin Hongli Chen Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice Journal of Innovative Optical Health Sciences Phototherapy photobiomodulation optogenetic sleep deprivation |
| title | Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice |
| title_full | Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice |
| title_fullStr | Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice |
| title_full_unstemmed | Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice |
| title_short | Phototherapy and optogenetic stimulation improve cognitive function in sleep-deprived mice |
| title_sort | phototherapy and optogenetic stimulation improve cognitive function in sleep deprived mice |
| topic | Phototherapy photobiomodulation optogenetic sleep deprivation |
| url | https://www.worldscientific.com/doi/10.1142/S1793545825500014 |
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