IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival.
<h4>Objective</h4>Increased inflammation, associated with the increase in chronic kidney disease (CKD) stage, has a very important influence in vascular injury and cardiovascular diseases. In this study, we aimed to investigate the levels of IL-33 and ST2 in the different stages of CKD a...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178939&type=printable |
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| author | Ozkan Gungor Hilmi Umut Unal Aydin Guclu Mustafa Gezer Tayfun Eyileten Fatma Betül Guzel Orcun Altunoren Ertugrul Erken Yusuf Oguz Ismail Kocyigit Mahmut Ilker Yilmaz |
| author_facet | Ozkan Gungor Hilmi Umut Unal Aydin Guclu Mustafa Gezer Tayfun Eyileten Fatma Betül Guzel Orcun Altunoren Ertugrul Erken Yusuf Oguz Ismail Kocyigit Mahmut Ilker Yilmaz |
| author_sort | Ozkan Gungor |
| collection | DOAJ |
| description | <h4>Objective</h4>Increased inflammation, associated with the increase in chronic kidney disease (CKD) stage, has a very important influence in vascular injury and cardiovascular diseases. In this study, we aimed to investigate the levels of IL-33 and ST2 in the different stages of CKD and to determine their effect on vascular damage and cardiovascular events (CVE).<h4>Methods</h4>This was an observational cohort study in which serum IL-33 and ST2 were obtained from 238 CKD (stages 1-5) patients. We examined the changes in IL-33/ST2 levels in CKD patients, as well as the association with a surrogate of endothelial dysfunction. Fatal and non-fatal CVE were recorded for a mean of 24 months. We also performed a COX regression analysis to determine the association of IL-33/ST2 levels with CVE and survival.<h4>Results</h4>IL-33 and ST2 levels were significantly increased and estimated glomerular filtration rates (eGFR) were decreased. Flow-mediated dilatation (FMD) was significantly decreased from stage 1 to stage 5 CKD. IL-33 and ST2 levels were associated with FMD, and ST2 was a predictor. Multivariate Cox analysis showed that the presence of diabetes mellitus, smoking, and proteinuria and haemoglobin, Hs-CRP, IL-33, and ST2 were associated with the risk of CVE. Kaplan-Meier survival curves showed that patients with IL-33 and ST2 levels below the median value (IL-33 = 132.6 ng/L, ST2 = 382.9 pg/mL) had a higher cumulative survival compared with patients who had IL-33 and ST2 levels above the median value (log-rank test, p = 0.000).<h4>Conclusion</h4>This is the first study that demonstrates that serum IL-33 and ST2 are associated with vascular injury, cardiovascular events, and survival in CKD patients. |
| format | Article |
| id | doaj-art-7bb287b2fd3e43abadf4beb40481bf54 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7bb287b2fd3e43abadf4beb40481bf542025-08-20T02:45:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017893910.1371/journal.pone.0178939IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival.Ozkan GungorHilmi Umut UnalAydin GucluMustafa GezerTayfun EyiletenFatma Betül GuzelOrcun AltunorenErtugrul ErkenYusuf OguzIsmail KocyigitMahmut Ilker Yilmaz<h4>Objective</h4>Increased inflammation, associated with the increase in chronic kidney disease (CKD) stage, has a very important influence in vascular injury and cardiovascular diseases. In this study, we aimed to investigate the levels of IL-33 and ST2 in the different stages of CKD and to determine their effect on vascular damage and cardiovascular events (CVE).<h4>Methods</h4>This was an observational cohort study in which serum IL-33 and ST2 were obtained from 238 CKD (stages 1-5) patients. We examined the changes in IL-33/ST2 levels in CKD patients, as well as the association with a surrogate of endothelial dysfunction. Fatal and non-fatal CVE were recorded for a mean of 24 months. We also performed a COX regression analysis to determine the association of IL-33/ST2 levels with CVE and survival.<h4>Results</h4>IL-33 and ST2 levels were significantly increased and estimated glomerular filtration rates (eGFR) were decreased. Flow-mediated dilatation (FMD) was significantly decreased from stage 1 to stage 5 CKD. IL-33 and ST2 levels were associated with FMD, and ST2 was a predictor. Multivariate Cox analysis showed that the presence of diabetes mellitus, smoking, and proteinuria and haemoglobin, Hs-CRP, IL-33, and ST2 were associated with the risk of CVE. Kaplan-Meier survival curves showed that patients with IL-33 and ST2 levels below the median value (IL-33 = 132.6 ng/L, ST2 = 382.9 pg/mL) had a higher cumulative survival compared with patients who had IL-33 and ST2 levels above the median value (log-rank test, p = 0.000).<h4>Conclusion</h4>This is the first study that demonstrates that serum IL-33 and ST2 are associated with vascular injury, cardiovascular events, and survival in CKD patients.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178939&type=printable |
| spellingShingle | Ozkan Gungor Hilmi Umut Unal Aydin Guclu Mustafa Gezer Tayfun Eyileten Fatma Betül Guzel Orcun Altunoren Ertugrul Erken Yusuf Oguz Ismail Kocyigit Mahmut Ilker Yilmaz IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival. PLoS ONE |
| title | IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival. |
| title_full | IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival. |
| title_fullStr | IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival. |
| title_full_unstemmed | IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival. |
| title_short | IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival. |
| title_sort | il 33 and st2 levels in chronic kidney disease associations with inflammation vascular abnormalities cardiovascular events and survival |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178939&type=printable |
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