The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models
Environmental endocrine disruptors constitute a category of exogenous compounds that interfere with the endocrine system's functions in organisms or cells. As a class of particularly representative endocrine-disrupting chemicals, the accumulation of per- and polyfluoroalkyl substances potential...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016919 |
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| author | Yalan Liu Fengzhong Wang Lin Li Bei Fan Zhiqiang Kong Jianxin Tan Minmin Li |
| author_facet | Yalan Liu Fengzhong Wang Lin Li Bei Fan Zhiqiang Kong Jianxin Tan Minmin Li |
| author_sort | Yalan Liu |
| collection | DOAJ |
| description | Environmental endocrine disruptors constitute a category of exogenous compounds that interfere with the endocrine system's functions in organisms or cells. As a class of particularly representative endocrine-disrupting chemicals, the accumulation of per- and polyfluoroalkyl substances potentially leads to adverse health effects, including hormonal disruptions, developmental issues, and cancer. However, the classification of these disruptors is intricate, and the data on their potential health risks is scattered. The research into fluorinated pesticides is somewhat superficial, with the majority of review articles in this field focusing on the structural characteristics, biodegradation processes, and environmental risks associated with these pesticides. In this study, we compared and investigated the research development processes of seven types of fluorine-containing pesticides and five types of fluorinated endocrine disruptors. The varying toxic effects of these endocrine disruptors are highly dependent on exposure conditions. Their actions are complex, affecting behavioral substances throughout the organism, and monitoring some complex biological phenotypes, sex- or age-specific effects, and behavioral learning poses significant challenges. The findings will serve as a reference for future studies on the toxicity of pesticides to humans and other organisms. |
| format | Article |
| id | doaj-art-7bb0642ca8644e18bbde307769d1c42b |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-7bb0642ca8644e18bbde307769d1c42b2025-01-23T05:25:53ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117615The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell modelsYalan Liu0Fengzhong Wang1Lin Li2Bei Fan3Zhiqiang Kong4Jianxin Tan5Minmin Li6College of Food Science and Technology, Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism, Hebei Agricultural University, Baoding, PR China; State Key Lab, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process/Laboratory of Agro-products Quality Safety Risk Assessment, Ministry of Agriculture and Rural Affairs, Beijing 100193, PR ChinaState Key Lab, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process/Laboratory of Agro-products Quality Safety Risk Assessment, Ministry of Agriculture and Rural Affairs, Beijing 100193, PR ChinaState Key Lab, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process/Laboratory of Agro-products Quality Safety Risk Assessment, Ministry of Agriculture and Rural Affairs, Beijing 100193, PR ChinaState Key Lab, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process/Laboratory of Agro-products Quality Safety Risk Assessment, Ministry of Agriculture and Rural Affairs, Beijing 100193, PR ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR ChinaCollege of Food Science and Technology, Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism, Hebei Agricultural University, Baoding, PR China; Corresponding authors.State Key Lab, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process/Laboratory of Agro-products Quality Safety Risk Assessment, Ministry of Agriculture and Rural Affairs, Beijing 100193, PR China; Corresponding authors.Environmental endocrine disruptors constitute a category of exogenous compounds that interfere with the endocrine system's functions in organisms or cells. As a class of particularly representative endocrine-disrupting chemicals, the accumulation of per- and polyfluoroalkyl substances potentially leads to adverse health effects, including hormonal disruptions, developmental issues, and cancer. However, the classification of these disruptors is intricate, and the data on their potential health risks is scattered. The research into fluorinated pesticides is somewhat superficial, with the majority of review articles in this field focusing on the structural characteristics, biodegradation processes, and environmental risks associated with these pesticides. In this study, we compared and investigated the research development processes of seven types of fluorine-containing pesticides and five types of fluorinated endocrine disruptors. The varying toxic effects of these endocrine disruptors are highly dependent on exposure conditions. Their actions are complex, affecting behavioral substances throughout the organism, and monitoring some complex biological phenotypes, sex- or age-specific effects, and behavioral learning poses significant challenges. The findings will serve as a reference for future studies on the toxicity of pesticides to humans and other organisms.http://www.sciencedirect.com/science/article/pii/S0147651324016919PesticidesEndocrine-disrupting effectEstrogen receptorCell modelsToxic mechanism |
| spellingShingle | Yalan Liu Fengzhong Wang Lin Li Bei Fan Zhiqiang Kong Jianxin Tan Minmin Li The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models Ecotoxicology and Environmental Safety Pesticides Endocrine-disrupting effect Estrogen receptor Cell models Toxic mechanism |
| title | The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models |
| title_full | The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models |
| title_fullStr | The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models |
| title_full_unstemmed | The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models |
| title_short | The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models |
| title_sort | potential endocrine disrupting of fluorinated pesticides and molecular mechanism of edps in cell models |
| topic | Pesticides Endocrine-disrupting effect Estrogen receptor Cell models Toxic mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016919 |
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