Effects of Inosine-5′-monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors on <i>Borrelia burgdorferi</i> Growth in Standard and Modified Culture Conditions

Effects of Inosine-5′-monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors on <i>Borrelia burgdorferi</i> Growth in Standard and Modified Culture Conditions

<i>Borrelia burgdorferi</i>’s inosine-5′-monophosphate dehydrogenase (IMPDH, GuaB encoded by the <i>guaB</i> gene) is a potential therapeutic target. GuaB is necessary for <i>B. burgdorferi</i> replication in mammalian hosts but not in standard laboratory culture...

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Bibliographic Details
Main Authors: Eric L. Siegel, Connor Rich, Sanchana Saravanan, Patrick Pearson, Guang Xu, Stephen M. Rich
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Microorganisms
Subjects:
<i>Borrelia burgdorferi</i>
inosine-5′-monophosphate dehydrogenase
GuaB
Lyme disease
Online Access:https://www.mdpi.com/2076-2607/12/10/2064
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