Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical Study
Background: Periodontitis is a chronic inflammatory condition that targets the structures supporting the teeth and has been linked to various systemic diseases, particularly cardiovascular conditions. The field of periodontal medicine highlights the influence of periodontitis on overall health, prim...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1787_24 |
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| author | Sapna Raje Ruchi Banthia Pallavi Singh Anshita Shrivastava Neha Mehrotra Santosh Gupta |
| author_facet | Sapna Raje Ruchi Banthia Pallavi Singh Anshita Shrivastava Neha Mehrotra Santosh Gupta |
| author_sort | Sapna Raje |
| collection | DOAJ |
| description | Background:
Periodontitis is a chronic inflammatory condition that targets the structures supporting the teeth and has been linked to various systemic diseases, particularly cardiovascular conditions. The field of periodontal medicine highlights the influence of periodontitis on overall health, primarily through inflammatory markers such as C-reactive protein (CRP) and fibrinogen.
Materials and Methods:
This randomized controlled prospective cohort study included 60 systemically healthy participants aged 30–60 years from Modern Dental College and Research Center, Indore. Participants were divided into two groups: Group I (30 periodontally healthy individuals, bleeding on probing (BOP) <20%) and Group II (30 chronic periodontitis patients, probing pocket depth (PPD) ≥4 mm in ≥30% of sites). Exclusion criteria were systemic diseases, smoking, alcohol use, and body mass index (BMI) ≥25 kg/m². Clinical parameters (BOP, PPD, clinical attachment loss (CAL), Vermillion’s Simplified Oral Hygiene Index (OHI-S)) and biochemical markers (CRP, plasma fibrinogen) were measured pre- and post-treatment. Group II received scaling and root planing, with follow-up after three weeks. Data were analyzed using SPSS (IBM corporation, USA), with significance set at P < 0.05.
Results:
Group II showed significantly higher BOP (1.00 ± 0.00 vs. 0.22 ± 0.03, P = 0.00) and PPD (5.99 ± 0.55 mm vs. 1.52 ± 0.27 mm, P = 0.00) compared to Group I. After therapy, BOP reduced to 0.31 ± 0.35, PPD to 3.54 ± 1.48 mm, and CAL improved from 6.15 ± 0.51 mm to 3.71 ± 1.49 mm (all P = 0.00). Serum CRP in Group II decreased from 1.99 ± 1.05 mg/L to 1.71 ± 0.62 mg/L (P = 0.017), and fibrinogen levels dropped from 2.16 ± 0.32 g/L to 1.86 ± 0.49 g/L (P = 0.003).
Conclusion:
Phase I periodontal therapy significantly improved clinical periodontal parameters, including BOP, PPD, and CAL, in patients with chronic periodontitis. The therapy also reduced systemic inflammatory markers, including CRP and fibrinogen. |
| format | Article |
| id | doaj-art-7baf205a18de4a6f859d4f72a84248f1 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-7baf205a18de4a6f859d4f72a84248f12025-08-20T03:31:33ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1430S143210.4103/jpbs.jpbs_1787_24Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical StudySapna RajeRuchi BanthiaPallavi SinghAnshita ShrivastavaNeha MehrotraSantosh GuptaBackground: Periodontitis is a chronic inflammatory condition that targets the structures supporting the teeth and has been linked to various systemic diseases, particularly cardiovascular conditions. The field of periodontal medicine highlights the influence of periodontitis on overall health, primarily through inflammatory markers such as C-reactive protein (CRP) and fibrinogen. Materials and Methods: This randomized controlled prospective cohort study included 60 systemically healthy participants aged 30–60 years from Modern Dental College and Research Center, Indore. Participants were divided into two groups: Group I (30 periodontally healthy individuals, bleeding on probing (BOP) <20%) and Group II (30 chronic periodontitis patients, probing pocket depth (PPD) ≥4 mm in ≥30% of sites). Exclusion criteria were systemic diseases, smoking, alcohol use, and body mass index (BMI) ≥25 kg/m². Clinical parameters (BOP, PPD, clinical attachment loss (CAL), Vermillion’s Simplified Oral Hygiene Index (OHI-S)) and biochemical markers (CRP, plasma fibrinogen) were measured pre- and post-treatment. Group II received scaling and root planing, with follow-up after three weeks. Data were analyzed using SPSS (IBM corporation, USA), with significance set at P < 0.05. Results: Group II showed significantly higher BOP (1.00 ± 0.00 vs. 0.22 ± 0.03, P = 0.00) and PPD (5.99 ± 0.55 mm vs. 1.52 ± 0.27 mm, P = 0.00) compared to Group I. After therapy, BOP reduced to 0.31 ± 0.35, PPD to 3.54 ± 1.48 mm, and CAL improved from 6.15 ± 0.51 mm to 3.71 ± 1.49 mm (all P = 0.00). Serum CRP in Group II decreased from 1.99 ± 1.05 mg/L to 1.71 ± 0.62 mg/L (P = 0.017), and fibrinogen levels dropped from 2.16 ± 0.32 g/L to 1.86 ± 0.49 g/L (P = 0.003). Conclusion: Phase I periodontal therapy significantly improved clinical periodontal parameters, including BOP, PPD, and CAL, in patients with chronic periodontitis. The therapy also reduced systemic inflammatory markers, including CRP and fibrinogen.https://journals.lww.com/10.4103/jpbs.jpbs_1787_24c-reactive proteinfibrinogencardiovascular diseasechronic periodontitisoral healthperiodontitisperiodontal therapysystemic inflammation |
| spellingShingle | Sapna Raje Ruchi Banthia Pallavi Singh Anshita Shrivastava Neha Mehrotra Santosh Gupta Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical Study Journal of Pharmacy and Bioallied Sciences c-reactive protein fibrinogen cardiovascular disease chronic periodontitis oral health periodontitis periodontal therapy systemic inflammation |
| title | Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical Study |
| title_full | Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical Study |
| title_fullStr | Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical Study |
| title_full_unstemmed | Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical Study |
| title_short | Evaluation of the Effect of Phase 1 Periodontal Therapy on Serum Procoagulant State of Systemically Healthy Chronic Periodontitis Subjects: A Clinico-Biochemical Study |
| title_sort | evaluation of the effect of phase 1 periodontal therapy on serum procoagulant state of systemically healthy chronic periodontitis subjects a clinico biochemical study |
| topic | c-reactive protein fibrinogen cardiovascular disease chronic periodontitis oral health periodontitis periodontal therapy systemic inflammation |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1787_24 |
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