25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus
ObjectiveTo analyze the risk factors for decreased heart rate variability (HRV) in elderly diabetic patients and evaluate the predictive value of 25-hydroxyvitamin D [25-(OH)D].MethodsA retrospective study was conducted, enrolling 101 elderly diabetic patients admitted to the Department of Geriatric...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1556345/full |
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| author | Tiantian Tang Xinyu Sun Xiaoxiang Zhang Jiaojiao Li Manjie Wang Cancan Hui Yuwei Cheng Xiaoming Kong Yan Sun |
| author_facet | Tiantian Tang Xinyu Sun Xiaoxiang Zhang Jiaojiao Li Manjie Wang Cancan Hui Yuwei Cheng Xiaoming Kong Yan Sun |
| author_sort | Tiantian Tang |
| collection | DOAJ |
| description | ObjectiveTo analyze the risk factors for decreased heart rate variability (HRV) in elderly diabetic patients and evaluate the predictive value of 25-hydroxyvitamin D [25-(OH)D].MethodsA retrospective study was conducted, enrolling 101 elderly diabetic patients admitted to the Department of Geriatric Endocrinology at the First Affiliated Hospital of Anhui Medical University from 2023 to 2024. Patients were divided into two groups based on the standard deviation of all normal RR intervals (SDNN) from 24-hour Holter monitoring: the normal HRV group (180 ms ≥ SDNN ≥ 100 ms) and the decreased HRV group (SDNN < 100 ms). Clinical data collected included age, sex, body mass index (BMI), Diabetic peripheral neuropathy (DPN), Diabetic peripheral vascular disease (DPVD), Diabetic nephropathy (DN), Diabetic retinopathy (DR), as well as laboratory parameters such as fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), creatinine (Cr), glomerular filtration rate (GFR), uric acid (UA), cystatin C (CysC), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), non-HDL-C, 25-(OH)D, 24-hour urinary total protein (24hUTP), 24-hour urinary uric acid (24hUA), microalbuminuria (MAlb), urinary albumin-to-creatinine ratio (UACR), and calculated ratios including TG/HDL-C, UA/HDL-C, and non-HDL-C/HDL-C. Statistical analyses included χ² test, independent t-test, Mann-Whitney U test, and multivariate logistic regression to identify risk factors for HRV reduction. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of these factors.ResultsCompared with the normal HRV group, the decreased HRV group had significantly lower HDL-C and 25-(OH)D levels but higher prevalence of DN, along with elevated 24hUTP, MAlb, UACR, TG/HDL-C, and UA/HDL-C (all P < 0.05). These factors were identified as independent risk factors for HRV reduction in elderly diabetic patients.ConclusionThis study identified key risk factors for HRV reduction in elderly diabetic patients. Furthermore, 25-(OH)D levels may serve as an early predictive marker for decreased HRV in this population. |
| format | Article |
| id | doaj-art-7babea6f628a44e6a2bf2e8108f659d6 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-7babea6f628a44e6a2bf2e8108f659d62025-08-20T03:13:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-04-011610.3389/fendo.2025.1556345155634525-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitusTiantian TangXinyu SunXiaoxiang ZhangJiaojiao LiManjie WangCancan HuiYuwei ChengXiaoming KongYan SunObjectiveTo analyze the risk factors for decreased heart rate variability (HRV) in elderly diabetic patients and evaluate the predictive value of 25-hydroxyvitamin D [25-(OH)D].MethodsA retrospective study was conducted, enrolling 101 elderly diabetic patients admitted to the Department of Geriatric Endocrinology at the First Affiliated Hospital of Anhui Medical University from 2023 to 2024. Patients were divided into two groups based on the standard deviation of all normal RR intervals (SDNN) from 24-hour Holter monitoring: the normal HRV group (180 ms ≥ SDNN ≥ 100 ms) and the decreased HRV group (SDNN < 100 ms). Clinical data collected included age, sex, body mass index (BMI), Diabetic peripheral neuropathy (DPN), Diabetic peripheral vascular disease (DPVD), Diabetic nephropathy (DN), Diabetic retinopathy (DR), as well as laboratory parameters such as fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), creatinine (Cr), glomerular filtration rate (GFR), uric acid (UA), cystatin C (CysC), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), non-HDL-C, 25-(OH)D, 24-hour urinary total protein (24hUTP), 24-hour urinary uric acid (24hUA), microalbuminuria (MAlb), urinary albumin-to-creatinine ratio (UACR), and calculated ratios including TG/HDL-C, UA/HDL-C, and non-HDL-C/HDL-C. Statistical analyses included χ² test, independent t-test, Mann-Whitney U test, and multivariate logistic regression to identify risk factors for HRV reduction. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of these factors.ResultsCompared with the normal HRV group, the decreased HRV group had significantly lower HDL-C and 25-(OH)D levels but higher prevalence of DN, along with elevated 24hUTP, MAlb, UACR, TG/HDL-C, and UA/HDL-C (all P < 0.05). These factors were identified as independent risk factors for HRV reduction in elderly diabetic patients.ConclusionThis study identified key risk factors for HRV reduction in elderly diabetic patients. Furthermore, 25-(OH)D levels may serve as an early predictive marker for decreased HRV in this population.https://www.frontiersin.org/articles/10.3389/fendo.2025.1556345/fullelderly diabetesheart rate variabilitycardiac autonomic neuropathy25-(OH)Ddiabetic nephropathy |
| spellingShingle | Tiantian Tang Xinyu Sun Xiaoxiang Zhang Jiaojiao Li Manjie Wang Cancan Hui Yuwei Cheng Xiaoming Kong Yan Sun 25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus Frontiers in Endocrinology elderly diabetes heart rate variability cardiac autonomic neuropathy 25-(OH)D diabetic nephropathy |
| title | 25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus |
| title_full | 25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus |
| title_fullStr | 25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus |
| title_full_unstemmed | 25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus |
| title_short | 25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus |
| title_sort | 25 hydroxyvitamin d as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus |
| topic | elderly diabetes heart rate variability cardiac autonomic neuropathy 25-(OH)D diabetic nephropathy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1556345/full |
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