α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence

α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence

Abstract Myocardial infarction (MI) has high morbidity and mortality, and the macrophage senescence-associated secretory phenotype (SASP) plays a central role in M1 healing. α-Lipoic acid (ALA) alleviates MI by regulating the function of macrophages, although the relationship between ALA and macroph...

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Bibliographic Details
Main Authors: Yuchao Wang, Yue Zheng, Xiaoyu Liang, Yun Chang, Yanwu Liu, Xian Cheng, Meng Zhang, Wenqing Gao, Tong Li
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Myocardial infarction
Macrophages
scRNA-sequence
Senescence
Oxidative stress
Inflammation
Online Access:https://doi.org/10.1038/s41598-025-92328-7
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