TGFβ2‐Driven Ferritin Degradation and Subsequent Ferroptosis Underlie Salivary Gland Dysfunction in Postmenopausal Conditions

TGFβ2‐Driven Ferritin Degradation and Subsequent Ferroptosis Underlie Salivary Gland Dysfunction in Postmenopausal Conditions

Abstract Despite the high incidence of dry mouth in postmenopausal women, its underlying mechanisms and therapeutic interventions remain underexplored. Using ovariectomized (OVX) mouse models, here this study identifies ferroptosis, an iron‐dependent regulated cell death, as a central mechanism driv...

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Main Authors: Su‐Jeong Oh, Ye Young Shin, Ji‐Su Ahn, Hee‐Jeong Park, Min‐Jung Kang, Tae‐Hoon Shin, Byung‐Chul Lee, Won Kyu Kim, Jung‐Min Oh, Dongjun Lee, Yun Hak Kim, Ji Min Kim, Eui‐Suk Sung, Eun‐Woo Lee, Jee‐Heon Jeong, Byung‐Joo Lee, Yoojin Seo, Hyung‐Sik Kim
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
estrogen
ferroptosis
organoids
salivary gland
TGFβ2
xerostomia
Online Access:https://doi.org/10.1002/advs.202400660
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