The relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertension
Abstract Platelet distribution width (PDW), which represents the heterogeneity of platelet size, can predict a poor prognosis in various populations. However, the PDW-to-serum albumin ratio (PAR) has not been evaluated in any disease population, and whether the PAR could be a prognostic marker in hy...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-05575-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849769183485624320 |
|---|---|
| author | Kenichi Tanaka Hiroshi Kimura Hirotaka Saito Michio Shimabukuro Koichi Asahi Tsuyoshi Watanabe Junichiro James Kazama |
| author_facet | Kenichi Tanaka Hiroshi Kimura Hirotaka Saito Michio Shimabukuro Koichi Asahi Tsuyoshi Watanabe Junichiro James Kazama |
| author_sort | Kenichi Tanaka |
| collection | DOAJ |
| description | Abstract Platelet distribution width (PDW), which represents the heterogeneity of platelet size, can predict a poor prognosis in various populations. However, the PDW-to-serum albumin ratio (PAR) has not been evaluated in any disease population, and whether the PAR could be a prognostic marker in hypertension remains unknown. The relationship between the PAR and adverse outcomes was examined retrospectively using longitudinal data of 1,578 patients with hypertension from the Fukushima Cohort Study. Participants were categorized into tertiles by baseline PAR. The primary endpoint of the present study was a kidney event, defined as a combination of a 50% decline in eGFR from baseline and end-stage kidney disease requiring kidney replacement therapy. During the median follow-up period of 5.4 years, 146 patients had kidney events. The higher PAR group (tertile 3) showed an increased incidence of kidney events on Kaplan–Meier curve analysis. Compared with the lowest PAR tertile, the highest PAR tertile (tertile 3) showed a significantly higher risk of kidney events (adjusted hazard ratio 3.74, 95% confidence interval (CI) 1.65–8.48). Similar relationships were observed for risks of all-cause death and cardiovascular events. The predictive value of the PAR for kidney events was superior to that of PDW alone. The areas under the curves for PDW and the PAR were 0.61 (95% CI 0.56–0.66) and 0.77 (95% CI 0.74–0.81), respectively (P < 0.001). The PAR could be a useful predictive marker of adverse outcomes in this population. |
| format | Article |
| id | doaj-art-7ba01c423f694381aaa3e459cb039eb0 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7ba01c423f694381aaa3e459cb039eb02025-08-20T03:03:32ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-05575-zThe relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertensionKenichi Tanaka0Hiroshi Kimura1Hirotaka Saito2Michio Shimabukuro3Koichi Asahi4Tsuyoshi Watanabe5Junichiro James Kazama6Department of Nephrology and Hypertension, Fukushima Medical UniversityDepartment of Nephrology and Hypertension, Fukushima Medical UniversityDepartment of Nephrology and Hypertension, Fukushima Medical UniversityDivision of Advanced Community Based Care for Lifestyle Related Diseases, Fukushima Medical UniversityDivision of Advanced Community Based Care for Lifestyle Related Diseases, Fukushima Medical UniversityDivision of Advanced Community Based Care for Lifestyle Related Diseases, Fukushima Medical UniversityDepartment of Nephrology and Hypertension, Fukushima Medical UniversityAbstract Platelet distribution width (PDW), which represents the heterogeneity of platelet size, can predict a poor prognosis in various populations. However, the PDW-to-serum albumin ratio (PAR) has not been evaluated in any disease population, and whether the PAR could be a prognostic marker in hypertension remains unknown. The relationship between the PAR and adverse outcomes was examined retrospectively using longitudinal data of 1,578 patients with hypertension from the Fukushima Cohort Study. Participants were categorized into tertiles by baseline PAR. The primary endpoint of the present study was a kidney event, defined as a combination of a 50% decline in eGFR from baseline and end-stage kidney disease requiring kidney replacement therapy. During the median follow-up period of 5.4 years, 146 patients had kidney events. The higher PAR group (tertile 3) showed an increased incidence of kidney events on Kaplan–Meier curve analysis. Compared with the lowest PAR tertile, the highest PAR tertile (tertile 3) showed a significantly higher risk of kidney events (adjusted hazard ratio 3.74, 95% confidence interval (CI) 1.65–8.48). Similar relationships were observed for risks of all-cause death and cardiovascular events. The predictive value of the PAR for kidney events was superior to that of PDW alone. The areas under the curves for PDW and the PAR were 0.61 (95% CI 0.56–0.66) and 0.77 (95% CI 0.74–0.81), respectively (P < 0.001). The PAR could be a useful predictive marker of adverse outcomes in this population.https://doi.org/10.1038/s41598-025-05575-zPlatelet distribution widthHypertensionKidneyObservational studyPrognosis |
| spellingShingle | Kenichi Tanaka Hiroshi Kimura Hirotaka Saito Michio Shimabukuro Koichi Asahi Tsuyoshi Watanabe Junichiro James Kazama The relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertension Scientific Reports Platelet distribution width Hypertension Kidney Observational study Prognosis |
| title | The relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertension |
| title_full | The relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertension |
| title_fullStr | The relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertension |
| title_full_unstemmed | The relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertension |
| title_short | The relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertension |
| title_sort | relationship of the ratio of platelet distribution width to serum albumin with kidney disease progression in patients with hypertension |
| topic | Platelet distribution width Hypertension Kidney Observational study Prognosis |
| url | https://doi.org/10.1038/s41598-025-05575-z |
| work_keys_str_mv | AT kenichitanaka therelationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT hiroshikimura therelationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT hirotakasaito therelationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT michioshimabukuro therelationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT koichiasahi therelationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT tsuyoshiwatanabe therelationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT junichirojameskazama therelationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT kenichitanaka relationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT hiroshikimura relationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT hirotakasaito relationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT michioshimabukuro relationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT koichiasahi relationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT tsuyoshiwatanabe relationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension AT junichirojameskazama relationshipoftheratioofplateletdistributionwidthtoserumalbuminwithkidneydiseaseprogressioninpatientswithhypertension |