Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population
Background. Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to i...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/973298 |
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| _version_ | 1832563713274544128 |
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| author | Johannes Lange Kristin Aaser Lunde Camilla Sletten Simon Geir Møller Ole-Bjørn Tysnes Guido Alves Jan Petter Larsen Jodi Maple-Grødem |
| author_facet | Johannes Lange Kristin Aaser Lunde Camilla Sletten Simon Geir Møller Ole-Bjørn Tysnes Guido Alves Jan Petter Larsen Jodi Maple-Grødem |
| author_sort | Johannes Lange |
| collection | DOAJ |
| description | Background. Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods. The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results. We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD. |
| format | Article |
| id | doaj-art-7b9864cf9dd84e68b540b481b65b56e5 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-7b9864cf9dd84e68b540b481b65b56e52025-02-03T01:12:44ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/973298973298Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian PopulationJohannes Lange0Kristin Aaser Lunde1Camilla Sletten2Simon Geir Møller3Ole-Bjørn Tysnes4Guido Alves5Jan Petter Larsen6Jodi Maple-Grødem7The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, NorwayThe Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, NorwayCentre for Organelle Research, University of Stavanger, 4036 Stavanger, NorwayDepartment of Biological Sciences, St. John’s University, New York, NY 11439, USADepartment of Neurology, Haukeland University Hospital, 5021 Bergen, NorwayThe Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, NorwayThe Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, NorwayThe Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, NorwayBackground. Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods. The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results. We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.http://dx.doi.org/10.1155/2015/973298 |
| spellingShingle | Johannes Lange Kristin Aaser Lunde Camilla Sletten Simon Geir Møller Ole-Bjørn Tysnes Guido Alves Jan Petter Larsen Jodi Maple-Grødem Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population Parkinson's Disease |
| title | Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population |
| title_full | Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population |
| title_fullStr | Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population |
| title_full_unstemmed | Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population |
| title_short | Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population |
| title_sort | association of a bace1 gene polymorphism with parkinson s disease in a norwegian population |
| url | http://dx.doi.org/10.1155/2015/973298 |
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