Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway

Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway

IntroductionIntestinal ischemia reperfusion (I/R) injury is a severe condition characterized by inflammation, oxidative stress, and compromised intestinal barrier function, which can lead to death. This study investigated the effects of paricalcitol, a synthetic vitamin D receptor (VDR) agonist, on...

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Bibliographic Details
Main Authors: Jiawei Zhang, Tingting Liu, Tongqing Xue, Zhongzhi Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
intestinal
ischemia reperfusion injury
paricalcitol
ATF4
CHOP
VDR (vitamin D receptor)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1529343/full
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