Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study
IntroductionFatty liver disease is potentially linked to chronic kidney disease (CKD), yet the association between the Framingham Steatosis Index (FSI) and CKD remains uncharted. Our study thoroughly investigated the correlation between FSI and CKD, aiming to elucidate the underlying links between t...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1518202/full |
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| author | Chunqi Jiang Bo Wang Jun Wang Yinuo Qu Xin Zhang Xin Zhang |
| author_facet | Chunqi Jiang Bo Wang Jun Wang Yinuo Qu Xin Zhang Xin Zhang |
| author_sort | Chunqi Jiang |
| collection | DOAJ |
| description | IntroductionFatty liver disease is potentially linked to chronic kidney disease (CKD), yet the association between the Framingham Steatosis Index (FSI) and CKD remains uncharted. Our study thoroughly investigated the correlation between FSI and CKD, aiming to elucidate the underlying links between these two conditions.MethodsThe relationship between FSI and CKD was evaluated using a weighted multivariate logistic regression model, and the curvilinear relationship between FSI and CKD was explored through smooth curve fitting. We engaged a recursive partitioning algorithm in conjunction with a two-stage linear regression model to determine the inflection point. By conducting stratified analyses, the heterogeneity within subpopulations was explored.ResultsIn the fully adjusted Model 3, which accounted for all covariates, the odds ratios (ORs) (95% CI) for the association between FSI and CKD were 1.01 (0.97, 1.06), indicating no significant statistical association. Sensitivity analysis confirms the stability of the relationship between FSI and CKD. Smooth curve fitting discloses a non-linear association between FSI and CKD. The two-piecewise linear regression model, applied to explore this non-linearity, identified an inflection point at an FSI value of −3.21. Below this threshold, the OR (95% CI) was 0.25 (0.17, 0.37), signifying an inverse correlation between FSI and CKD. Above the inflection point, the OR (95% CI) was 1.19 (1.13, 1.25), suggesting a positive correlation. In the stratified curve analysis, the results were essentially consistent with the overall findings, except for the subgroups with BMI > 30 and age > 50.ConclusionWe found a curvilinear relationship between FSI and CKD. |
| format | Article |
| id | doaj-art-7b94a71c15224db5b8423e369a164baa |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-7b94a71c15224db5b8423e369a164baa2025-01-14T06:10:40ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15182021518202Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional studyChunqi Jiang0Bo Wang1Jun Wang2Yinuo Qu3Xin Zhang4Xin Zhang5Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaCentral Hospital of Jinan City, Jinan, Shandong, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaCollege of Acupuncture - Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaIntroductionFatty liver disease is potentially linked to chronic kidney disease (CKD), yet the association between the Framingham Steatosis Index (FSI) and CKD remains uncharted. Our study thoroughly investigated the correlation between FSI and CKD, aiming to elucidate the underlying links between these two conditions.MethodsThe relationship between FSI and CKD was evaluated using a weighted multivariate logistic regression model, and the curvilinear relationship between FSI and CKD was explored through smooth curve fitting. We engaged a recursive partitioning algorithm in conjunction with a two-stage linear regression model to determine the inflection point. By conducting stratified analyses, the heterogeneity within subpopulations was explored.ResultsIn the fully adjusted Model 3, which accounted for all covariates, the odds ratios (ORs) (95% CI) for the association between FSI and CKD were 1.01 (0.97, 1.06), indicating no significant statistical association. Sensitivity analysis confirms the stability of the relationship between FSI and CKD. Smooth curve fitting discloses a non-linear association between FSI and CKD. The two-piecewise linear regression model, applied to explore this non-linearity, identified an inflection point at an FSI value of −3.21. Below this threshold, the OR (95% CI) was 0.25 (0.17, 0.37), signifying an inverse correlation between FSI and CKD. Above the inflection point, the OR (95% CI) was 1.19 (1.13, 1.25), suggesting a positive correlation. In the stratified curve analysis, the results were essentially consistent with the overall findings, except for the subgroups with BMI > 30 and age > 50.ConclusionWe found a curvilinear relationship between FSI and CKD.https://www.frontiersin.org/articles/10.3389/fmed.2024.1518202/fullFramingham Steatosis Indexchronic kidney diseasecurvilinearNHANEScross-sectional study |
| spellingShingle | Chunqi Jiang Bo Wang Jun Wang Yinuo Qu Xin Zhang Xin Zhang Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study Frontiers in Medicine Framingham Steatosis Index chronic kidney disease curvilinear NHANES cross-sectional study |
| title | Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study |
| title_full | Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study |
| title_fullStr | Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study |
| title_full_unstemmed | Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study |
| title_short | Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study |
| title_sort | curvilinear association between framingham steatosis index and chronic kidney disease a nationwide cross sectional study |
| topic | Framingham Steatosis Index chronic kidney disease curvilinear NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1518202/full |
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