A cellular triad for linking cardiac niche to regeneration
Abstract Cardiovascular disease is the leading cause of mortality with very limited therapeutic interventions, thus holding great hope for cardiac regenerative medicine. A recent work from Martin’s laboratory reports their identification of a fetal-like cardiomyocyte progenitor, adult cardiomyocyte...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-12-01
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| Series: | Cell Regeneration |
| Online Access: | https://doi.org/10.1186/s13619-024-00213-x |
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| _version_ | 1850256119870521344 |
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| author | Xiaokai Ma Junjie Hou Jing-Wei Xiong |
| author_facet | Xiaokai Ma Junjie Hou Jing-Wei Xiong |
| author_sort | Xiaokai Ma |
| collection | DOAJ |
| description | Abstract Cardiovascular disease is the leading cause of mortality with very limited therapeutic interventions, thus holding great hope for cardiac regenerative medicine. A recent work from Martin’s laboratory reports their identification of a fetal-like cardiomyocyte progenitor, adult cardiomyocyte type 2 (aCM2), and its potential interactions with C3+ cardiac fibroblasts and C3ar1+ macrophages to form a regenerative cellular triad, which is only present in the regenerative heart models, YAP5SA-expressing adult hearts and neonatal hearts. The complement signaling is essential for cellular interactions in this regenerative triad. This Highlight summarizes these major findings and provides brief perspectives on the impact of this regenerative niche during cardiac regeneration in the future. |
| format | Article |
| id | doaj-art-7b934bd23d544dd2a8e40d257ab776c3 |
| institution | OA Journals |
| issn | 2045-9769 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj-art-7b934bd23d544dd2a8e40d257ab776c32025-08-20T01:56:42ZengSpringerOpenCell Regeneration2045-97692024-12-011311310.1186/s13619-024-00213-xA cellular triad for linking cardiac niche to regenerationXiaokai Ma0Junjie Hou1Jing-Wei Xiong2Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, and College of Future Technology, Peking UniversitySchool of Basic Medical Sciences, Institute of Biomedical Innovation, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityBeijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, and College of Future Technology, Peking UniversityAbstract Cardiovascular disease is the leading cause of mortality with very limited therapeutic interventions, thus holding great hope for cardiac regenerative medicine. A recent work from Martin’s laboratory reports their identification of a fetal-like cardiomyocyte progenitor, adult cardiomyocyte type 2 (aCM2), and its potential interactions with C3+ cardiac fibroblasts and C3ar1+ macrophages to form a regenerative cellular triad, which is only present in the regenerative heart models, YAP5SA-expressing adult hearts and neonatal hearts. The complement signaling is essential for cellular interactions in this regenerative triad. This Highlight summarizes these major findings and provides brief perspectives on the impact of this regenerative niche during cardiac regeneration in the future.https://doi.org/10.1186/s13619-024-00213-x |
| spellingShingle | Xiaokai Ma Junjie Hou Jing-Wei Xiong A cellular triad for linking cardiac niche to regeneration Cell Regeneration |
| title | A cellular triad for linking cardiac niche to regeneration |
| title_full | A cellular triad for linking cardiac niche to regeneration |
| title_fullStr | A cellular triad for linking cardiac niche to regeneration |
| title_full_unstemmed | A cellular triad for linking cardiac niche to regeneration |
| title_short | A cellular triad for linking cardiac niche to regeneration |
| title_sort | cellular triad for linking cardiac niche to regeneration |
| url | https://doi.org/10.1186/s13619-024-00213-x |
| work_keys_str_mv | AT xiaokaima acellulartriadforlinkingcardiacnichetoregeneration AT junjiehou acellulartriadforlinkingcardiacnichetoregeneration AT jingweixiong acellulartriadforlinkingcardiacnichetoregeneration AT xiaokaima cellulartriadforlinkingcardiacnichetoregeneration AT junjiehou cellulartriadforlinkingcardiacnichetoregeneration AT jingweixiong cellulartriadforlinkingcardiacnichetoregeneration |