High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study

High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study

BackgroundMultiple sclerosis (MS) is a neuroinflammatory disease triggered by a combination of genetic traits and external factors. Autoimmune nature of MS is proven by the identification of pathogenic T cells, but the role of autoantibody-producing B cells is less clear. A comprehensive understandi...

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Main Authors: Leyla A. Ovchinnikova, Igor E. Eliseev, Samir S. Dzhelad, Taras O. Simaniv, Ksenia M. Klimina, Maria Ivanova, Elena N. Ilina, Maria N. Zakharova, Sergey N. Illarioshkin, Yury P. Rubtsov, Alexander G. Gabibov, Yakov A. Lomakin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
SPTAN1
Epstein-Barr virus
LMP1
autoantibody
autoantigen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1401156/full
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