In silico improvement of affinity for highly protective anti-malarial antibodies

In silico improvement of affinity for highly protective anti-malarial antibodies

Summary: The monoclonal antibody CIS43 preferentially binds the junctional region of Plasmodium falciparum circumsporozoite protein (PfCSP) and is highly protective in humans. Here, we develop an in silico pipeline to improve antigen-antibody interaction energies and apply it to CIS43 variants elici...

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Main Authors: Mateo Reveiz, Prabhanshu Tripathi, Lais Da Silva Pereira, Patience Kerubo Kiyuka, Tracy Liu, Yongping Yang, Baoshan Zhang, Dorra Benmohamed, Brian G. Bonilla, Carl W. Carruthers, Jr., Marlon Dillon, Daniel Gowetski, Sven Kratochvil, Gabriella Lagos, Mariah Lofgren, Ivan Loukinov, Shamika Mathis-Torres, Andrew J. Schaub, Elizabeth Scheideman, Arne Schön, Chen-Hsiang Shen, Yevel Flores-Garcia, Fidel Zavala, Facundo D. Batista, Azza H. Idris, Robert A. Seder, Peter D. Kwong, Reda Rawi
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Biological sciences
Immunology
Natural sciences
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011642
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http://www.sciencedirect.com/science/article/pii/S2589004225011642

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