Characteristics and impact of real-world evidence studies in oncology: comprehensive mapping review of publications evaluating targeted therapies in solid tumours
Background: A mapping review of real-world evidence (RWE) publications on targeted therapy (TT) for solid tumours was carried out to describe their characteristics, strengths, and limitations. Methods: RWE publications were identified that: (i) focused on TTs in patients with solid tumours; (ii) inc...
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Elsevier
2024-12-01
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| Series: | ESMO Real World Data and Digital Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949820124000699 |
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| author | A. Pellat T. Grinda P. Cresta Morgado A. Prelaj V. Miskovic A. Valachis I. Zerdes D. Martins-Branco L. Provenzano A. Spagnoletti G. Nader-Marta B.E. Wilson Y.-H. Yang G. Pentheroudakis S. Delaloge L. Castelo-Branco M. Koopman |
| author_facet | A. Pellat T. Grinda P. Cresta Morgado A. Prelaj V. Miskovic A. Valachis I. Zerdes D. Martins-Branco L. Provenzano A. Spagnoletti G. Nader-Marta B.E. Wilson Y.-H. Yang G. Pentheroudakis S. Delaloge L. Castelo-Branco M. Koopman |
| author_sort | A. Pellat |
| collection | DOAJ |
| description | Background: A mapping review of real-world evidence (RWE) publications on targeted therapy (TT) for solid tumours was carried out to describe their characteristics, strengths, and limitations. Methods: RWE publications were identified that: (i) focused on TTs in patients with solid tumours; (ii) included study objectives of effectiveness, predictive or prognostic factors, safety or quality of life; (iii) were published between 1 January 2020 and 22 December 2022. Associations between study variables and journal impact factor (IF) were explored through regression and cluster network analyses. Results: Of 7775 publications identified, 1251 were eligible for analysis. The number of publications per year increased over time. Most studies were conducted in Asia (50%), Europe (25%), and North America (17%), with only 8% in more than one country. Data sources were mostly health records (55%) and registries (11%). Most studies were retrospective (85%) and only 16% were population based. Gastrointestinal tumours were the most frequently studied (30%), followed by lung (22%) and breast (21%). The median journal IF was 4.4. Involvement of >10 centres and studies originating from Europe were significantly associated with a higher IF (≥7) in multivariable analysis. Network analysis demonstrated strong associations between countries and the number of publications in specific tumour types. Conclusions: The number of RWE publications on TT for solid tumours is increasing, but studies are heterogeneous, mostly retrospective, and published in low IF journals. International collaboration and promotion of standardised data sources is imperative to enhance the relevance of RWE research to complement clinical guidelines and impact clinical practice. |
| format | Article |
| id | doaj-art-7b8ad1ead3cf4e088d4d86448b2870df |
| institution | OA Journals |
| issn | 2949-8201 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | ESMO Real World Data and Digital Oncology |
| spelling | doaj-art-7b8ad1ead3cf4e088d4d86448b2870df2025-08-20T02:29:36ZengElsevierESMO Real World Data and Digital Oncology2949-82012024-12-01610009110.1016/j.esmorw.2024.100091Characteristics and impact of real-world evidence studies in oncology: comprehensive mapping review of publications evaluating targeted therapies in solid tumoursA. Pellat0T. Grinda1P. Cresta Morgado2A. Prelaj3V. Miskovic4A. Valachis5I. Zerdes6D. Martins-Branco7L. Provenzano8A. Spagnoletti9G. Nader-Marta10B.E. Wilson11Y.-H. Yang12G. Pentheroudakis13S. Delaloge14L. Castelo-Branco15M. Koopman16Department of Gastroenterology, Endoscopy and Digestive Oncology, Hôpital Cochin APHP, Paris, France; Center for Research in Epidemiology and Statistics (CRESS-U1153), Université Paris Cité and Université Sorbonne Paris Nord, INRAE, Inserm, Hôpital Hôtel-Dieu, Paris, France; Correspondence to: Dr Anna Pellat, Department of Gastroenterology, Endoscopy and Digestive Oncology, Hôpital Cochin APHP, 27 rue du Faubourg Saint Jacques, 75014 Paris, France. Tel: +33158411921Department of Cancer Medicine, Gustave Roussy, Villejuif, FranceProstate Cancer Translational Research Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain; Oncology Data Science, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, SpainMedical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, ItalyMedical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, ItalyDepartment of Oncology, Faculty of Medicine and Health, Örebro University Hospital, Örebro University, Örebro, SwedenDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden; Theme Center, Karolinska University Hospital, Karolinska Comprehensive Cancer Center, Stockholm, SwedenScientific and Medical Division, European Society for Medical Oncology, Lugano, SwitzerlandMedical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Department of Electronics, Information, and Bioengineering, Politecnico di Milano, Milan, ItalyMedical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyAcademic Trials Promoting Team (ATPT), Institut Jules Bordet, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, BelgiumDepartment of Oncology, Queen’s University, Kingston, Canada; Division of Cancer Care and Epidemiology, Queen’s Cancer Research Institute, Kingston, CanadaNational Institute of Cancer Research, National Health Research Institutes, Tainan, TaiwanScientific and Medical Division, European Society for Medical Oncology, Lugano, SwitzerlandDepartment of Cancer Medicine, Gustave Roussy, Villejuif, FranceMedical Oncology Division, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, SwitzerlandDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsBackground: A mapping review of real-world evidence (RWE) publications on targeted therapy (TT) for solid tumours was carried out to describe their characteristics, strengths, and limitations. Methods: RWE publications were identified that: (i) focused on TTs in patients with solid tumours; (ii) included study objectives of effectiveness, predictive or prognostic factors, safety or quality of life; (iii) were published between 1 January 2020 and 22 December 2022. Associations between study variables and journal impact factor (IF) were explored through regression and cluster network analyses. Results: Of 7775 publications identified, 1251 were eligible for analysis. The number of publications per year increased over time. Most studies were conducted in Asia (50%), Europe (25%), and North America (17%), with only 8% in more than one country. Data sources were mostly health records (55%) and registries (11%). Most studies were retrospective (85%) and only 16% were population based. Gastrointestinal tumours were the most frequently studied (30%), followed by lung (22%) and breast (21%). The median journal IF was 4.4. Involvement of >10 centres and studies originating from Europe were significantly associated with a higher IF (≥7) in multivariable analysis. Network analysis demonstrated strong associations between countries and the number of publications in specific tumour types. Conclusions: The number of RWE publications on TT for solid tumours is increasing, but studies are heterogeneous, mostly retrospective, and published in low IF journals. International collaboration and promotion of standardised data sources is imperative to enhance the relevance of RWE research to complement clinical guidelines and impact clinical practice.http://www.sciencedirect.com/science/article/pii/S2949820124000699mapping reviewnetwork analysisoncologyreal-world evidencesolid tumourstargeted therapy |
| spellingShingle | A. Pellat T. Grinda P. Cresta Morgado A. Prelaj V. Miskovic A. Valachis I. Zerdes D. Martins-Branco L. Provenzano A. Spagnoletti G. Nader-Marta B.E. Wilson Y.-H. Yang G. Pentheroudakis S. Delaloge L. Castelo-Branco M. Koopman Characteristics and impact of real-world evidence studies in oncology: comprehensive mapping review of publications evaluating targeted therapies in solid tumours ESMO Real World Data and Digital Oncology mapping review network analysis oncology real-world evidence solid tumours targeted therapy |
| title | Characteristics and impact of real-world evidence studies in oncology: comprehensive mapping review of publications evaluating targeted therapies in solid tumours |
| title_full | Characteristics and impact of real-world evidence studies in oncology: comprehensive mapping review of publications evaluating targeted therapies in solid tumours |
| title_fullStr | Characteristics and impact of real-world evidence studies in oncology: comprehensive mapping review of publications evaluating targeted therapies in solid tumours |
| title_full_unstemmed | Characteristics and impact of real-world evidence studies in oncology: comprehensive mapping review of publications evaluating targeted therapies in solid tumours |
| title_short | Characteristics and impact of real-world evidence studies in oncology: comprehensive mapping review of publications evaluating targeted therapies in solid tumours |
| title_sort | characteristics and impact of real world evidence studies in oncology comprehensive mapping review of publications evaluating targeted therapies in solid tumours |
| topic | mapping review network analysis oncology real-world evidence solid tumours targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2949820124000699 |
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