Central Insulin-Like Growth Factor-1-Induced Anxiolytic and Antidepressant Effects in a Rat Model of Sporadic Alzheimer’s Disease Are Associated with the Peripheral Suppression of Inflammation

Central Insulin-Like Growth Factor-1-Induced Anxiolytic and Antidepressant Effects in a Rat Model of Sporadic Alzheimer’s Disease Are Associated with the Peripheral Suppression of Inflammation

(1) Insulin-like growth factor-1 (IGF-1) is a neurotrophin with anti-inflammatory properties. Neuroinflammation and stress activate peripheral immune mechanisms, which may contribute to the development of depression and anxiety in sporadic Alzheimer’s disease (sAD). This study aims to evaluate wheth...

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Bibliographic Details
Main Authors: Joanna Dunacka, Beata Grembecka, Danuta Wrona
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Cells
Subjects:
sporadic Alzheimer’s disease model
insulin-like growth factor-1
anhedonia
anxiety
peripheral inflammation
Online Access:https://www.mdpi.com/2073-4409/14/15/1189
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