Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis
Objectives Anatomical variation of the sacroiliac (SI) joints is common and specific variants are associated with erosions and bone marrow oedema on imaging. Our investigation aims to evaluate whether anatomical variations influence the clinical presentation of axial spondyloarthritis (axSpA).Method...
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BMJ Publishing Group
2025-02-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/11/1/e004923.full |
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| author | Denis Poddubnyy Torsten Diekhoff Sevtap Tugce Ulas Fabian Proft Valeria Rios Rodriguez Judith Rademacher Juliane Greese Katharina Ziegeler Carolina Dominguez Aleixo Maximilian Lindholz |
| author_facet | Denis Poddubnyy Torsten Diekhoff Sevtap Tugce Ulas Fabian Proft Valeria Rios Rodriguez Judith Rademacher Juliane Greese Katharina Ziegeler Carolina Dominguez Aleixo Maximilian Lindholz |
| author_sort | Denis Poddubnyy |
| collection | DOAJ |
| description | Objectives Anatomical variation of the sacroiliac (SI) joints is common and specific variants are associated with erosions and bone marrow oedema on imaging. Our investigation aims to evaluate whether anatomical variations influence the clinical presentation of axial spondyloarthritis (axSpA).Methods In this propensity score matched post hoc analysis documented clinical data from four prospective clinical cohorts was assessed. Classification of back pain as inflammatory (=IBP), human leucocyte antigen-B27 positivity, family history, disease activity according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), symptom duration, elevated acute phase reactants, peripheral and extramusculoskeletal manifestations were evaluated. Statistical analyses were done using (generalised) linear models, t-tests, χ2 tests and analysis of variances. Multiple testing was corrected according to Bonferroni.Results A total of 165 patients (86 women) were included. Atypical SI joints, defined by the presence of accessory joint facets, iliosacral complex or crescent-shaped ilii on MRI, were identified in 61 out of 165 patients with axSpA. Disease activity, assessed by BASDAI and symptom duration were similar in both groups (adjusted ß=−0.118 (95% CI -0.713, 0.476), p=0.696 and 120.0 (107.4) vs 116.5 (98.3) months, p=0.838, respectively). There was no significant difference in IBP between the groups (adjusted OR=0.614 (95% CI 0.274, 1.377), p=0.236). Sex-stratified analysis revealed no statistically significant results.Conclusion Our analysis suggests that clinical phenotypes do not significantly differ between patients with axSpA with and without atypical joints. |
| format | Article |
| id | doaj-art-7b6e8905f6da46ff929dcb1d9de6be01 |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
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| series | RMD Open |
| spelling | doaj-art-7b6e8905f6da46ff929dcb1d9de6be012025-02-09T05:15:08ZengBMJ Publishing GroupRMD Open2056-59332025-02-0111110.1136/rmdopen-2024-004923Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysisDenis Poddubnyy0Torsten Diekhoff1Sevtap Tugce Ulas2Fabian Proft3Valeria Rios Rodriguez4Judith Rademacher5Juliane Greese6Katharina Ziegeler7Carolina Dominguez Aleixo8Maximilian Lindholz9Department of Gastroenterology, Infectiology and Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Berlin, GermanyDepartment of Radiology, Charité University Hospital Berlin, Berlin, GermanyDepartment of Radiology, Charité University Hospital Berlin, Berlin, GermanyDepartment of Gastroenterology, Infectiology and Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Berlin, GermanyDepartment of Gastroenterology, Infectiology and Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Berlin, GermanyDepartment of Gastroenterology, Infectiology and Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Berlin, GermanyDepartment of Radiology, Charité University Hospital Berlin, Berlin, GermanyRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USADepartment of Radiology, Charité University Hospital Berlin, Berlin, GermanyDepartment of Radiology, Charité University Hospital Berlin, Berlin, GermanyObjectives Anatomical variation of the sacroiliac (SI) joints is common and specific variants are associated with erosions and bone marrow oedema on imaging. Our investigation aims to evaluate whether anatomical variations influence the clinical presentation of axial spondyloarthritis (axSpA).Methods In this propensity score matched post hoc analysis documented clinical data from four prospective clinical cohorts was assessed. Classification of back pain as inflammatory (=IBP), human leucocyte antigen-B27 positivity, family history, disease activity according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), symptom duration, elevated acute phase reactants, peripheral and extramusculoskeletal manifestations were evaluated. Statistical analyses were done using (generalised) linear models, t-tests, χ2 tests and analysis of variances. Multiple testing was corrected according to Bonferroni.Results A total of 165 patients (86 women) were included. Atypical SI joints, defined by the presence of accessory joint facets, iliosacral complex or crescent-shaped ilii on MRI, were identified in 61 out of 165 patients with axSpA. Disease activity, assessed by BASDAI and symptom duration were similar in both groups (adjusted ß=−0.118 (95% CI -0.713, 0.476), p=0.696 and 120.0 (107.4) vs 116.5 (98.3) months, p=0.838, respectively). There was no significant difference in IBP between the groups (adjusted OR=0.614 (95% CI 0.274, 1.377), p=0.236). Sex-stratified analysis revealed no statistically significant results.Conclusion Our analysis suggests that clinical phenotypes do not significantly differ between patients with axSpA with and without atypical joints.https://rmdopen.bmj.com/content/11/1/e004923.full |
| spellingShingle | Denis Poddubnyy Torsten Diekhoff Sevtap Tugce Ulas Fabian Proft Valeria Rios Rodriguez Judith Rademacher Juliane Greese Katharina Ziegeler Carolina Dominguez Aleixo Maximilian Lindholz Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis RMD Open |
| title | Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis |
| title_full | Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis |
| title_fullStr | Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis |
| title_full_unstemmed | Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis |
| title_short | Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis |
| title_sort | influence of sacroiliac joint variation on clinical features of axial spondyloarthritis a comparative analysis |
| url | https://rmdopen.bmj.com/content/11/1/e004923.full |
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