Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective
Compounds isolated from Epimedium include the total flavonoids of Epimedium, icariin, and its metabolites (icaritin, icariside I, and icariside II), which have similar molecular structures. Modern pharmacological research and clinical practice have proved that Epimedium and its active components hav...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Asian Journal of Andrology |
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| Online Access: | https://journals.lww.com/10.4103/aja20248 |
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| author | Song-Po Liu Yun-Fei Li Dan Zhang Chun-Yang Li Xiao-Fang Dai Dong-Feng Lan Ji Cai He Zhou Tao Song Yan-Yu Zhao Zhi-Xu He Jun Tan Ji-Dong Zhang |
| author_facet | Song-Po Liu Yun-Fei Li Dan Zhang Chun-Yang Li Xiao-Fang Dai Dong-Feng Lan Ji Cai He Zhou Tao Song Yan-Yu Zhao Zhi-Xu He Jun Tan Ji-Dong Zhang |
| author_sort | Song-Po Liu |
| collection | DOAJ |
| description | Compounds isolated from Epimedium include the total flavonoids of Epimedium, icariin, and its metabolites (icaritin, icariside I, and icariside II), which have similar molecular structures. Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects, especially in improving sexual function, hormone regulation, anti-osteoporosis, immune function regulation, anti-oxidation, and anti-tumor activity. To date, we still need a comprehensive source of knowledge about the pharmacological effects of Epimedium and its bioactive compounds on the male reproductive system. However, their actions in other tissues have been reviewed in recent years. This review critically focuses on the Epimedium, its bioactive compounds, and the biochemical and molecular mechanisms that modulate vital pathways associated with the male reproductive system. Such intrinsic knowledge will significantly further studies on the Epimedium and its bioactive compounds that protect the male reproductive system and provide some guidances for clinical treatment of related male reproductive disorders. |
| format | Article |
| id | doaj-art-7b6d9dc048554713b4ed46d2fdafb6b3 |
| institution | OA Journals |
| issn | 1008-682X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj-art-7b6d9dc048554713b4ed46d2fdafb6b32025-08-20T02:02:12ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X2025-01-01271202910.4103/aja20248Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspectiveSong-Po LiuYun-Fei LiDan ZhangChun-Yang LiXiao-Fang DaiDong-Feng LanJi CaiHe ZhouTao SongYan-Yu ZhaoZhi-Xu HeJun TanJi-Dong ZhangCompounds isolated from Epimedium include the total flavonoids of Epimedium, icariin, and its metabolites (icaritin, icariside I, and icariside II), which have similar molecular structures. Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects, especially in improving sexual function, hormone regulation, anti-osteoporosis, immune function regulation, anti-oxidation, and anti-tumor activity. To date, we still need a comprehensive source of knowledge about the pharmacological effects of Epimedium and its bioactive compounds on the male reproductive system. However, their actions in other tissues have been reviewed in recent years. This review critically focuses on the Epimedium, its bioactive compounds, and the biochemical and molecular mechanisms that modulate vital pathways associated with the male reproductive system. Such intrinsic knowledge will significantly further studies on the Epimedium and its bioactive compounds that protect the male reproductive system and provide some guidances for clinical treatment of related male reproductive disorders.https://journals.lww.com/10.4103/aja20248epimediumicariininfertilitymale reproductive systemtumor |
| spellingShingle | Song-Po Liu Yun-Fei Li Dan Zhang Chun-Yang Li Xiao-Fang Dai Dong-Feng Lan Ji Cai He Zhou Tao Song Yan-Yu Zhao Zhi-Xu He Jun Tan Ji-Dong Zhang Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective Asian Journal of Andrology epimedium icariin infertility male reproductive system tumor |
| title | Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective |
| title_full | Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective |
| title_fullStr | Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective |
| title_full_unstemmed | Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective |
| title_short | Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective |
| title_sort | pharmacological actions of the bioactive compounds of epimedium on the male reproductive system current status and future perspective |
| topic | epimedium icariin infertility male reproductive system tumor |
| url | https://journals.lww.com/10.4103/aja20248 |
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