Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propensity score matching study
Objectives To compare the long-term outcomes of microwave ablation (MWA) for primary hepatocellular carcinoma (HCC) in patients with metabolic-associated fatty liver disease (MAFLD) with those infected by hepatitis virus B (HBV).Methods The clinical data of HCC patients under the treatment of MWA we...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2419912 |
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| author | Yannan Qiao Sitong Chen Yang Liu Lu Li Liting He Zhiyu Han Fangyi Liu Zhigang Cheng Xiaoling Yu Jie Yu Chuan Pang Ping Liang |
| author_facet | Yannan Qiao Sitong Chen Yang Liu Lu Li Liting He Zhiyu Han Fangyi Liu Zhigang Cheng Xiaoling Yu Jie Yu Chuan Pang Ping Liang |
| author_sort | Yannan Qiao |
| collection | DOAJ |
| description | Objectives To compare the long-term outcomes of microwave ablation (MWA) for primary hepatocellular carcinoma (HCC) in patients with metabolic-associated fatty liver disease (MAFLD) with those infected by hepatitis virus B (HBV).Methods The clinical data of HCC patients under the treatment of MWA were analyzed retrospectively between 2010 and 2021 at Chinese PLA General Hospital. Patients were divided into MAFLD-HCC and HBV-HCC group according to the chronic liver disease etiology. The propensity score matching (PSM) was performed to reduce the interference of confounders. The primary outcomes were overall survival (OS), recurrence-free survival (RFS), cancer-specific survival (CSS) and intrahepatic distant recurrence (IDR).Results A total of 648 patients (age range, 18–91 years) with 1019 lesions were enrolled including 601 with HBV-HCC and 47 with MAFLD-HCC. After a variable ratio of 1:n ≤ 4 PSM, 100 patients were included in the HBV-HCC and 41 in the MAFLD-HCC group. No statistical differences in OS and CSS (p = 0.880 and p = 0.980, respectively) were observed between the two groups in the matched cohort, while MAFLD-HCC exhibited better RFS and lower IDR rates compared to HBV-HCC (p = 0.043 and p = 0.041, respectively). Additionally, MAFLD-HCC generated lower ascending range in the liver function indexes like ΔALT (46.7 vs. 98.5, p < 0.001), ΔTBIL (1.9 vs. 7.5, p = 0.001) and ΔAST (38.1 vs. 148.6, p < 0.001) than HBV-HCC after MWA.Conclusions MWA is an effective treatment for HCC patients with MAFLD. The recurrence prognosis of MAFLD-HCC was better than HBV-HCC and the degree of liver injury after MWA was lower. |
| format | Article |
| id | doaj-art-7b670c175d3741af894cc18fc98deef4 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-7b670c175d3741af894cc18fc98deef42025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2419912Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propensity score matching studyYannan Qiao0Sitong Chen1Yang Liu2Lu Li3Liting He4Zhiyu Han5Fangyi Liu6Zhigang Cheng7Xiaoling Yu8Jie Yu9Chuan Pang10Ping Liang11Department of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The First Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaObjectives To compare the long-term outcomes of microwave ablation (MWA) for primary hepatocellular carcinoma (HCC) in patients with metabolic-associated fatty liver disease (MAFLD) with those infected by hepatitis virus B (HBV).Methods The clinical data of HCC patients under the treatment of MWA were analyzed retrospectively between 2010 and 2021 at Chinese PLA General Hospital. Patients were divided into MAFLD-HCC and HBV-HCC group according to the chronic liver disease etiology. The propensity score matching (PSM) was performed to reduce the interference of confounders. The primary outcomes were overall survival (OS), recurrence-free survival (RFS), cancer-specific survival (CSS) and intrahepatic distant recurrence (IDR).Results A total of 648 patients (age range, 18–91 years) with 1019 lesions were enrolled including 601 with HBV-HCC and 47 with MAFLD-HCC. After a variable ratio of 1:n ≤ 4 PSM, 100 patients were included in the HBV-HCC and 41 in the MAFLD-HCC group. No statistical differences in OS and CSS (p = 0.880 and p = 0.980, respectively) were observed between the two groups in the matched cohort, while MAFLD-HCC exhibited better RFS and lower IDR rates compared to HBV-HCC (p = 0.043 and p = 0.041, respectively). Additionally, MAFLD-HCC generated lower ascending range in the liver function indexes like ΔALT (46.7 vs. 98.5, p < 0.001), ΔTBIL (1.9 vs. 7.5, p = 0.001) and ΔAST (38.1 vs. 148.6, p < 0.001) than HBV-HCC after MWA.Conclusions MWA is an effective treatment for HCC patients with MAFLD. The recurrence prognosis of MAFLD-HCC was better than HBV-HCC and the degree of liver injury after MWA was lower.https://www.tandfonline.com/doi/10.1080/02656736.2024.2419912Hepatocellular carcinomamicrowave ablationmetabolic-associated fatty liver diseasehepatitis virus Bultrasound |
| spellingShingle | Yannan Qiao Sitong Chen Yang Liu Lu Li Liting He Zhiyu Han Fangyi Liu Zhigang Cheng Xiaoling Yu Jie Yu Chuan Pang Ping Liang Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propensity score matching study International Journal of Hyperthermia Hepatocellular carcinoma microwave ablation metabolic-associated fatty liver disease hepatitis virus B ultrasound |
| title | Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propensity score matching study |
| title_full | Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propensity score matching study |
| title_fullStr | Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propensity score matching study |
| title_full_unstemmed | Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propensity score matching study |
| title_short | Ultrasound-guided percutaneous microwave ablation for metabolic-associated fatty liver disease-related hepatocellular carcinoma (HCC) versus hepatitis virus B-related HCC: a propensity score matching study |
| title_sort | ultrasound guided percutaneous microwave ablation for metabolic associated fatty liver disease related hepatocellular carcinoma hcc versus hepatitis virus b related hcc a propensity score matching study |
| topic | Hepatocellular carcinoma microwave ablation metabolic-associated fatty liver disease hepatitis virus B ultrasound |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2419912 |
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