Alzheimer's disease and insomnia: a bibliometric study and visualization analysis
BackgroundAlzheimer's disease (AD) is the fastest-growing neurodegenerative disorder globally, with patient numbers expected to rise to 130 million by 2050. Insomnia, a prevalent comorbidity, exhibits a bidirectional relationship with AD: insomnia accelerates AD pathology, while AD worsens slee...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1542607/full |
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| author | Zi-Yue Tian Bing Jiang Meng Jin Xiao-Kun Yu Qi-Lin Chen Qi-Lin Chen Jia-Hui Wang |
| author_facet | Zi-Yue Tian Bing Jiang Meng Jin Xiao-Kun Yu Qi-Lin Chen Qi-Lin Chen Jia-Hui Wang |
| author_sort | Zi-Yue Tian |
| collection | DOAJ |
| description | BackgroundAlzheimer's disease (AD) is the fastest-growing neurodegenerative disorder globally, with patient numbers expected to rise to 130 million by 2050. Insomnia, a prevalent comorbidity, exhibits a bidirectional relationship with AD: insomnia accelerates AD pathology, while AD worsens sleep disorders. This relationship has emerged as a key area of research. Current mechanisms involve oxidative stress, inflammatory responses, and glymphatic system dysfunction, yet a comprehensive review of these processes remains absent.ObjectiveTo conduct a visual analysis of the relationship between Alzheimer's disease and insomnia using CiteSpace.MethodsLiterature on “insomnia” and “Alzheimer's disease” published between January 1, 2000, and October 31, 2024, was retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to analyze institutions, authors, and keywords.ResultsA total of 1,907 articles were analyzed, revealing a consistent upward trend in publication volume. The United States and the Mayo Clinic were identified as leading contributors, producing 704 and 57 publications, respectively. Boeve Bradley F the most prolific author contributed 30 publications. Collaboration was actively observed among countries, institutions, and authors. High-frequency keywords identified were “Parkinson's disease,” “cognitive impairment,” and “sleep behavior disorder.” Emerging research areas are likely to focus on “sleep quality” and the “glymphatic system.”ConclusionThis study is the first to apply bibliometric analysis to identify three key trends in AD and insomnia research: the dominance of the United States and Mayo Clinic, strong international collaboration, and a focus on critical areas such as cognitive impairment, the glymphatic system, and sleep interventions. Insomnia may accelerate AD progression via multiple pathways, indicating that enhancing sleep quality could provide new strategies for early intervention. Future research should prioritize advancing the clinical translation of sleep interventions and investigating the mechanisms of the glymphatic system. |
| format | Article |
| id | doaj-art-7b5d97374c5e46b283a2f7b9ed45bfe5 |
| institution | DOAJ |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-7b5d97374c5e46b283a2f7b9ed45bfe52025-08-20T03:17:43ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-04-011710.3389/fnagi.2025.15426071542607Alzheimer's disease and insomnia: a bibliometric study and visualization analysisZi-Yue Tian0Bing Jiang1Meng Jin2Xiao-Kun Yu3Qi-Lin Chen4Qi-Lin Chen5Jia-Hui Wang6Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, ChinaDepartment of Integrated Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaThe Third Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin, ChinaThe Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin, ChinaDepartment of Integrated Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, ChinaKweiChow Moutai Hospital, Zunyi, Guizhou, ChinaHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, ChinaBackgroundAlzheimer's disease (AD) is the fastest-growing neurodegenerative disorder globally, with patient numbers expected to rise to 130 million by 2050. Insomnia, a prevalent comorbidity, exhibits a bidirectional relationship with AD: insomnia accelerates AD pathology, while AD worsens sleep disorders. This relationship has emerged as a key area of research. Current mechanisms involve oxidative stress, inflammatory responses, and glymphatic system dysfunction, yet a comprehensive review of these processes remains absent.ObjectiveTo conduct a visual analysis of the relationship between Alzheimer's disease and insomnia using CiteSpace.MethodsLiterature on “insomnia” and “Alzheimer's disease” published between January 1, 2000, and October 31, 2024, was retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to analyze institutions, authors, and keywords.ResultsA total of 1,907 articles were analyzed, revealing a consistent upward trend in publication volume. The United States and the Mayo Clinic were identified as leading contributors, producing 704 and 57 publications, respectively. Boeve Bradley F the most prolific author contributed 30 publications. Collaboration was actively observed among countries, institutions, and authors. High-frequency keywords identified were “Parkinson's disease,” “cognitive impairment,” and “sleep behavior disorder.” Emerging research areas are likely to focus on “sleep quality” and the “glymphatic system.”ConclusionThis study is the first to apply bibliometric analysis to identify three key trends in AD and insomnia research: the dominance of the United States and Mayo Clinic, strong international collaboration, and a focus on critical areas such as cognitive impairment, the glymphatic system, and sleep interventions. Insomnia may accelerate AD progression via multiple pathways, indicating that enhancing sleep quality could provide new strategies for early intervention. Future research should prioritize advancing the clinical translation of sleep interventions and investigating the mechanisms of the glymphatic system.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1542607/fullbibliometricsCiteSpaceVOSviewervisual analysisinsomniaAlzheimer's disease |
| spellingShingle | Zi-Yue Tian Bing Jiang Meng Jin Xiao-Kun Yu Qi-Lin Chen Qi-Lin Chen Jia-Hui Wang Alzheimer's disease and insomnia: a bibliometric study and visualization analysis Frontiers in Aging Neuroscience bibliometrics CiteSpace VOSviewer visual analysis insomnia Alzheimer's disease |
| title | Alzheimer's disease and insomnia: a bibliometric study and visualization analysis |
| title_full | Alzheimer's disease and insomnia: a bibliometric study and visualization analysis |
| title_fullStr | Alzheimer's disease and insomnia: a bibliometric study and visualization analysis |
| title_full_unstemmed | Alzheimer's disease and insomnia: a bibliometric study and visualization analysis |
| title_short | Alzheimer's disease and insomnia: a bibliometric study and visualization analysis |
| title_sort | alzheimer s disease and insomnia a bibliometric study and visualization analysis |
| topic | bibliometrics CiteSpace VOSviewer visual analysis insomnia Alzheimer's disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1542607/full |
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