Toxicities and management strategies of emerging antibody–drug conjugates in breast cancer
Antibody–drug conjugates (ADCs) offer a promising therapeutic approach for various cancers, enhancing the therapeutic window while mitigating systemic adverse effects on healthy tissues. ADCs have achieved remarkable clinical success, particularly in treating breast cancer, becoming a standard thera...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-03-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/17588359251324889 |
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| _version_ | 1850098918524715008 |
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| author | Sora Kang Sung-Bae Kim |
| author_facet | Sora Kang Sung-Bae Kim |
| author_sort | Sora Kang |
| collection | DOAJ |
| description | Antibody–drug conjugates (ADCs) offer a promising therapeutic approach for various cancers, enhancing the therapeutic window while mitigating systemic adverse effects on healthy tissues. ADCs have achieved remarkable clinical success, particularly in treating breast cancer, becoming a standard therapy across all subtypes, including hormone receptor-positive, human epidermal growth factor receptor 2-positive, and triple-negative breast cancer. Although designed to selectively target antigens via monoclonal antibodies, ADCs can exhibit toxicity in normal tissues, often due to off-target effects of their cytotoxic payloads. Understanding and managing these toxicities according to established guidelines are crucial for enhancing ADC clinical efficacy, minimizing adverse events, and ultimately improving patient outcomes. This review comprehensively examines the toxicities of ADCs employed in breast cancer treatment and explores their management strategies. Furthermore, we investigate novel ADCs beyond trastuzumab deruxtecan and sacituzumab govitecan, evaluating their potential efficacy and corresponding safety profiles. |
| format | Article |
| id | doaj-art-7b5b875133ed4754b5706d17324744fb |
| institution | DOAJ |
| issn | 1758-8359 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj-art-7b5b875133ed4754b5706d17324744fb2025-08-20T02:40:36ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592025-03-011710.1177/17588359251324889Toxicities and management strategies of emerging antibody–drug conjugates in breast cancerSora KangSung-Bae KimAntibody–drug conjugates (ADCs) offer a promising therapeutic approach for various cancers, enhancing the therapeutic window while mitigating systemic adverse effects on healthy tissues. ADCs have achieved remarkable clinical success, particularly in treating breast cancer, becoming a standard therapy across all subtypes, including hormone receptor-positive, human epidermal growth factor receptor 2-positive, and triple-negative breast cancer. Although designed to selectively target antigens via monoclonal antibodies, ADCs can exhibit toxicity in normal tissues, often due to off-target effects of their cytotoxic payloads. Understanding and managing these toxicities according to established guidelines are crucial for enhancing ADC clinical efficacy, minimizing adverse events, and ultimately improving patient outcomes. This review comprehensively examines the toxicities of ADCs employed in breast cancer treatment and explores their management strategies. Furthermore, we investigate novel ADCs beyond trastuzumab deruxtecan and sacituzumab govitecan, evaluating their potential efficacy and corresponding safety profiles.https://doi.org/10.1177/17588359251324889 |
| spellingShingle | Sora Kang Sung-Bae Kim Toxicities and management strategies of emerging antibody–drug conjugates in breast cancer Therapeutic Advances in Medical Oncology |
| title | Toxicities and management strategies of emerging antibody–drug conjugates in breast cancer |
| title_full | Toxicities and management strategies of emerging antibody–drug conjugates in breast cancer |
| title_fullStr | Toxicities and management strategies of emerging antibody–drug conjugates in breast cancer |
| title_full_unstemmed | Toxicities and management strategies of emerging antibody–drug conjugates in breast cancer |
| title_short | Toxicities and management strategies of emerging antibody–drug conjugates in breast cancer |
| title_sort | toxicities and management strategies of emerging antibody drug conjugates in breast cancer |
| url | https://doi.org/10.1177/17588359251324889 |
| work_keys_str_mv | AT sorakang toxicitiesandmanagementstrategiesofemergingantibodydrugconjugatesinbreastcancer AT sungbaekim toxicitiesandmanagementstrategiesofemergingantibodydrugconjugatesinbreastcancer |