Effect of high-flux dialysis on the levels of AGEs and microinflammation in patients with diabetic kidney disease
Objective To investigate the effect of high-flux dialysis on the levels of AGEs,CRP,IL-6 and TNF-α in patients with diabetic kidney disease（DKD）. M ethods Sixty patients with early DKD were enrolled in this study during October 2015 to November 2017.Thirty patients in experimental group received hig...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2018-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57915643&Fpath=home&index=0 |
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| Summary: | Objective To investigate the effect of high-flux dialysis on the levels of AGEs,CRP,IL-6 and TNF-α in patients with diabetic kidney disease（DKD）. M ethods Sixty patients with early DKD were enrolled in this study during October 2015 to November 2017.Thirty patients in experimental group received high-flux dialysis with ultrafiltration coefficient of 40 ml·h<sup>-1</sup>·mm Hg<sup>-1</sup>,and 30 patients in control group received conventional hemodialysis with ultrafiltration coefficient of 16 ml·h<sup>-1</sup>·mm Hg<sup>-1</sup>,3 times per week,4 h each,for 2 months. The levels of AGEs,CRP,IL-6 and TNF-α pre-and post-dialysis were measured. Results The levels of AGEs,CRP,IL-6 and TNF-α in the experimental group were higher than in the control group and the difference was statistically significant（P < 0. 0 5）. The levels of AGEs,CRP,TNF-αand IL-6 in the experimental group were significantly lower than those before dialysis（P < 0.05）after single and continuous high-flux dialysis. There was no significant change in the AGEs level after a single conventional hemodialysis,while the levels of CRP,TNF-α and IL-6 in the control group were significantly increased（P < 0.05）. After continuous conventional hemodialysis,the levels of AGEs increased,while the levels of TNF-α increased further（P < 0.05）. Conclusions Patients with DKD were in obvious inflammatory state,and high-throughput dialysis can remove AGEs,CRP,IL-6,TNF-α effectively. Compared with conventional hemodialysis,high-flux dialysis benefits patients with DKD. |
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| ISSN: | 1671-2390 |