Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.

Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.

Merozoite Surface Protein 1 is expressed on the surface of malaria merozoites and is important for invasion of the malaria parasite into erythrocytes. MSP1-specific CD4 T cell responses and antibody can confer protective immunity in experimental models of malaria. In this study we explore the contri...

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Main Authors: Calogero Tulone, Anne-Marit Sponaas, Eun-Ang Raiber, Alethea B Tabor, Jean Langhorne, Benny M Chain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024886&type=printable
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