The predictive value of the neutrophil/eosinophil ratio in cancer patients undergoing immune checkpoint inhibition: a meta-analysis and a validation cohort in hepatocellular carcinoma

The predictive value of the neutrophil/eosinophil ratio in cancer patients undergoing immune checkpoint inhibition: a meta-analysis and a validation cohort in hepatocellular carcinoma

ObjectiveThis study was conducted to determine the prognostic relevance of neutrophil/eosinophil ratio (NER) in cancer patients receiving immune checkpoint inhibition therapy.MethodsA comprehensive search of the literature was carried out across PubMed, EMBASE, and the Cochrane Library to identify r...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yang Xu, Yang Liu, Huimin Han, Zhen He, Wei Cao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Immunology
Subjects:	immune checkpoint inhibitors neutrophil-to-eosinophil ratio prognosis cancer hepatocellular carcinoma
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1633034/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Prognostic value of the neutrophil-to-lymphocyte ratio and prognostic nutritional index in unresectable hepatocellular carcinoma patients treated with tyrosine kinase inhibitors and immune checkpoint inhibitors
by: Shasha Sun, et al.
Published: (2024-12-01)

Prognostic value of platelet-to-lymphocyte ratio in hepatocellular carcinoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
by: Qingtian Zhou, et al.
Published: (2025-06-01)

The Association of Blood Eosinophils and Neutrophils Expressing Eosinophilic Surface Markers with the Severity and Outcome of COVID-19
by: Jun Wang, et al.
Published: (2024-12-01)

Differential Analysis of Hemogram Parameters and Cellular Ratios in Severe Asthma Exacerbations: A Comparative Study of Eosinophilic and Non-Eosinophilic Phenotypes
by: Nicolae Demenciuc, et al.
Published: (2025-06-01)

Neutrophil and neutrophil-lymphocyte ratios as predictors of clinical characteristics in patients with Lymphangioleiomyomatosis
by: Lulu Yang, et al.
Published: (2025-06-01)

Prognostic value of the lactate dehydrogenase to albumin ratio in cancer patients
by: Dongqi Chai, et al.
Published: (2025-07-01)

Successful management of chronic eosinophilic pneumonia triggered by immune checkpoint inhibitor: a case report and literature review
by: Yasuhito Suzuki, et al.
Published: (2025-07-01)

Predictive Value of Neutrophil‐to‐Lymphocyte Ratio for Immune Checkpoint Inhibitor‐Related Myocarditis Among Patients Treated for Non‐Small‐Cell Lung Cancer
by: Jian Xue, et al.
Published: (2025-04-01)

MERTK inhibition improves therapeutic efficacy of immune checkpoint inhibitors in hepatocellular carcinoma
by: Diana Llopiz, et al.
Published: (2025-12-01)

Distinct Airway Microbiome and Metabolite Profiles in Eosinophilic and Neutrophilic Asthma
by: Liu S, et al.
Published: (2025-06-01)

Eosinophil-to-Neutrophil Ratio and Eosinophil Count as the Potential Biomarkers for Differentiating Breast Cancer Stage: A Retrospective Study
by: Phey Liana, et al.
Published: (2025-01-01)

Splenic volume as a predictor of survival in cancer patients treated with immune checkpoint inhibitors
by: Yunhua Zhang, et al.
Published: (2025-05-01)

Comparison of serum zinc levels between patients with sinonasal neutrophilic and eosinophilic inflammatory polyposis and healthy individuals
by: Matin Ghazizadeh, et al.
Published: (2024-11-01)

Prognostic impact of extracellular volume fraction derived from equilibrium contrast-enhanced CT in HCC patients receiving immune checkpoint inhibitors
by: Xiaona Fu, et al.
Published: (2025-04-01)

Relationship between eosinopenia and neutrophil-lymphocyte ratio with sepsis-related mortality in the intensive care unit
by: Parviz Amri, et al.
Published: (2025-06-01)

Prognostic value of neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma receiving curative therapies: a systematic review and meta-analysis
by: Jinxiang Peng, et al.
Published: (2025-03-01)

Dynamic Neutrophil-to-Lymphocyte Ratio at 3-4 weeks of Intensity-Modulated Radiotherapy Combined with Normal Liver Volume Predicts Radiation-Induced Hepatic Toxicity in Hepatocellular Carcinoma: A Retrospective Study
by: Chen L, et al.
Published: (2025-06-01)

The role of T-helper and T regulatory cells in driving neutrophilic and eosinophilic inflammation in bronchiectasis
by: Evangelia Fouka, et al.
Published: (2025-06-01)

MRI Features and Neutrophil-to-Lymphocyte Ratio (NLR)-Based Nomogram to Predict Prognosis of Microvascular Invasion-Negative Hepatocellular Carcinoma
by: Wei Y, et al.
Published: (2025-02-01)

Development and validation of a prognostic nomogram incorporating neutrophil-to-albumin ratio for predicting overall survival in patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy
by: Xin Hua, et al.
Published: (2025-01-01)

The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study
by: Li D, et al.
Published: (2025-07-01)

Evaluation of Treatment Outcomes Using dNLR and GNRI in Combination Therapy With Atezolizumab and Bevacizumab for Hepatocellular Carcinoma
by: Atsushi Naganuma, et al.
Published: (2025-01-01)

Peritumor tertiary lymphoid structures are associated with infiltrating neutrophils and inferior prognosis in hepatocellular carcinoma
by: Tianchen Zhang, et al.
Published: (2023-02-01)

Nomogram based on the neutrophil-to-lymphocyte ratio and MR diffusion quantitative parameters for predicting Ki67 expression in hepatocellular carcinoma from a prospective study
by: Yu-chen Wei, et al.
Published: (2024-12-01)

Managing hepatocellular carcinoma recurrence after liver transplantation: emerging role of immune checkpoint inhibitors
by: Mohammad Saeid Rezaee-Zavareh, et al.
Published: (2025-07-01)

Spleen Volume Dynamics and Survival Outcomes in HCC Patients Undergoing Immune Checkpoint Inhibitors: A Retrospective Analysis
by: Fu X, et al.
Published: (2025-05-01)

Analysis of the correlation between neutrophil percentage-to-albumin ratio, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with short-term prognosis in acute ischemic stroke patients undergoing intravenous thrombolysis
by: Congcong Deng, et al.
Published: (2025-04-01)

The impact of immune checkpoint inhibitors on prognosis in unresectable hepatocellular carcinoma treated with TACE and lenvatinib: a meta-analysis
by: Wei Zhang, et al.
Published: (2025-05-01)

Evaluation of S100A8/A9 and neutrophils as prognostic markers in metastatic melanoma patients under immune-checkpoint inhibition
by: Yasmin F Melzer, et al.
Published: (2025-02-01)

Elevated Neutrophil‐to‐Lymphocyte Ratio Correlates With Liver Metastases and Poor Immunotherapy Response in Stage IV Melanoma
by: Yannick Foerster, et al.
Published: (2025-02-01)

Characteristics and outcomes of primary and secondary resistance to immune checkpoint inhibitors in hepatocellular carcinoma
by: Xiaowen Cui, et al.
Published: (2025-06-01)

THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA
by: Alpay Medetalibeyoğlu, et al.
Published: (2021-01-01)

Prognostic Significance of Preoperative Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Patients with Ruptured Abdominal Aortic Aneurysm Undergoing Endovascular Aneurysm Repair
by: Biao Wu, et al.
Published: (2024-12-01)

Transarterial chemoembolization combined with tyrosine kinase inhibitors and/or immune checkpoint inhibitors induced hypothyroidism is associated with improved overall survival in hepatocellular carcinoma
by: Shengyuan Xu, et al.
Published: (2025-05-01)

Neutrophil-to-lymphocyte ratio dynamics: prognostic value and potential for surveilling glioblastoma recurrence
by: Meng-Wu Chung, et al.
Published: (2025-04-01)

The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer
by: Rumeysa Çolak, et al.
Published: (2025-08-01)

Safety and clinical efficacy of immune checkpoint inhibitors in pediatric hepatocellular carcinoma: a case report and review of the literature
by: Xiaoting Zhong, et al.
Published: (2025-08-01)

Preoperative and Postoperative Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Measured From the Peripheral Blood of Patients with Colorectal Cancer
by: Lu HJ, et al.
Published: (2025-03-01)

Neutrophil-to-lymphocyte ratio: A surrogate marker for prognosis of oral squamous cell carcinoma
by: R Mahalakshmi, et al.
Published: (2018-01-01)

Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma
by: Guichuan Lai, et al.
Published: (2025-05-01)