Magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model
Abstract Background Magnetic particle imaging (MPI) allows for radiation-free visualization of tracers without background signal. With the first human-sized interventional MPI scanner being recently developed, the aim of the present study was to test its performance for guiding of endovascular proce...
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Nature Portfolio
2025-03-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-025-00794-x |
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| author | Viktor Hartung Philipp Gruschwitz Anne Marie Augustin Jan-Peter Grunz Florian Kleefeldt Dominik Peter Süleyman Ergün Johanna Günther Teresa Reichl Thomas Kampf Martin Andreas Rückert Stefan Herz Volker Christian Behr Thorsten Alexander Bley Patrick Vogel |
| author_facet | Viktor Hartung Philipp Gruschwitz Anne Marie Augustin Jan-Peter Grunz Florian Kleefeldt Dominik Peter Süleyman Ergün Johanna Günther Teresa Reichl Thomas Kampf Martin Andreas Rückert Stefan Herz Volker Christian Behr Thorsten Alexander Bley Patrick Vogel |
| author_sort | Viktor Hartung |
| collection | DOAJ |
| description | Abstract Background Magnetic particle imaging (MPI) allows for radiation-free visualization of tracers without background signal. With the first human-sized interventional MPI scanner being recently developed, the aim of the present study was to test its performance for guiding of endovascular procedures in a realistic perfusion model. Methods Three fresh-frozen cadaveric legs were prepared to establish continuous circulation in the superficial femoral artery via introducer sheaths in the inguinal and infragenicular region. To facilitate vessel visualization, a mixture of a MPI tracer (Resotran® or Perimag®) and X-ray contrast agent was injected under continuous extracorporeal perfusion and imaged simultaneously with MPI angiography and digital subtraction angiography (DSA) as reference. Results The MPI scanner integrates seamlessly into the standard operating procedures in the angiography suite and simultaneous imaging with DSA and MPI is feasible. The MPI scanner detects a tracer bolus of 2 ml Perimag® or 1.5 ml Resotran®. Imaging results are consistent and reproducible in three cadaveric leg phantoms. Conclusion This study demonstrates, that the recently developed human-sized MPI scanner facilitates reliable radiation-free image guidance for peripheral vascular interventions in the superficial femoral artery with a tracer approved for use in humans. |
| format | Article |
| id | doaj-art-7b528a1b52ca422bb54a92ae71ae4c70 |
| institution | DOAJ |
| issn | 2730-664X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
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| series | Communications Medicine |
| spelling | doaj-art-7b528a1b52ca422bb54a92ae71ae4c702025-08-20T02:56:12ZengNature PortfolioCommunications Medicine2730-664X2025-03-015111010.1038/s43856-025-00794-xMagnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion modelViktor Hartung0Philipp Gruschwitz1Anne Marie Augustin2Jan-Peter Grunz3Florian Kleefeldt4Dominik Peter5Süleyman Ergün6Johanna Günther7Teresa Reichl8Thomas Kampf9Martin Andreas Rückert10Stefan Herz11Volker Christian Behr12Thorsten Alexander Bley13Patrick Vogel14Department of Diagnostic and Interventional Radiology, University Hospital WürzburgDepartment of Diagnostic and Interventional Radiology, University Hospital WürzburgDepartment of Diagnostic and Interventional Radiology, University Hospital WürzburgDepartment of Diagnostic and Interventional Radiology, University Hospital WürzburgInstitute of Anatomy and Cell Biology, Julius-Maximilians UniversityDepartment of General, Visceral, Transplant, Vascular and Pediatric Surgery, Center of Operative Medicine, University Hospital WürzburgInstitute of Anatomy and Cell Biology, Julius-Maximilians UniversityDepartment of Experimental Physics 5 (Biophysics), Julius-Maximilians UniversityDepartment of Experimental Physics 5 (Biophysics), Julius-Maximilians UniversityDepartment of Experimental Physics 5 (Biophysics), Julius-Maximilians UniversityDepartment of Experimental Physics 5 (Biophysics), Julius-Maximilians UniversityDepartment of Diagnostic and Interventional Radiology, University Hospital WürzburgDepartment of Experimental Physics 5 (Biophysics), Julius-Maximilians UniversityDepartment of Diagnostic and Interventional Radiology, University Hospital WürzburgDepartment of Experimental Physics 5 (Biophysics), Julius-Maximilians UniversityAbstract Background Magnetic particle imaging (MPI) allows for radiation-free visualization of tracers without background signal. With the first human-sized interventional MPI scanner being recently developed, the aim of the present study was to test its performance for guiding of endovascular procedures in a realistic perfusion model. Methods Three fresh-frozen cadaveric legs were prepared to establish continuous circulation in the superficial femoral artery via introducer sheaths in the inguinal and infragenicular region. To facilitate vessel visualization, a mixture of a MPI tracer (Resotran® or Perimag®) and X-ray contrast agent was injected under continuous extracorporeal perfusion and imaged simultaneously with MPI angiography and digital subtraction angiography (DSA) as reference. Results The MPI scanner integrates seamlessly into the standard operating procedures in the angiography suite and simultaneous imaging with DSA and MPI is feasible. The MPI scanner detects a tracer bolus of 2 ml Perimag® or 1.5 ml Resotran®. Imaging results are consistent and reproducible in three cadaveric leg phantoms. Conclusion This study demonstrates, that the recently developed human-sized MPI scanner facilitates reliable radiation-free image guidance for peripheral vascular interventions in the superficial femoral artery with a tracer approved for use in humans.https://doi.org/10.1038/s43856-025-00794-x |
| spellingShingle | Viktor Hartung Philipp Gruschwitz Anne Marie Augustin Jan-Peter Grunz Florian Kleefeldt Dominik Peter Süleyman Ergün Johanna Günther Teresa Reichl Thomas Kampf Martin Andreas Rückert Stefan Herz Volker Christian Behr Thorsten Alexander Bley Patrick Vogel Magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model Communications Medicine |
| title | Magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model |
| title_full | Magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model |
| title_fullStr | Magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model |
| title_full_unstemmed | Magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model |
| title_short | Magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model |
| title_sort | magnetic particle imaging angiography of the femoral artery in a human cadaveric perfusion model |
| url | https://doi.org/10.1038/s43856-025-00794-x |
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