Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast China
Objective Kidney disease has become a significant public health issue. Socioeconomic improvements and environmental changes in China have influenced the kidney disease spectrum. This study aims to examine the changing spectrum of biopsy-confirmed kidney diseases in a single center from southeastern...
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PeerJ Inc.
2025-04-01
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| author | Zishan Lin Shidong Xie Wenfeng Wang Tao Hong Bingjing Jiang Caiming Chen Xuan Tao Dewen Jiang Jianxin Wan Hong Chen Yanfang Xu |
| author_facet | Zishan Lin Shidong Xie Wenfeng Wang Tao Hong Bingjing Jiang Caiming Chen Xuan Tao Dewen Jiang Jianxin Wan Hong Chen Yanfang Xu |
| author_sort | Zishan Lin |
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| description | Objective Kidney disease has become a significant public health issue. Socioeconomic improvements and environmental changes in China have influenced the kidney disease spectrum. This study aims to examine the changing spectrum of biopsy-confirmed kidney diseases in a single center from southeastern China and explore their clinical-pathological correlations. Methods Patients who underwent renal biopsy at the First Affiliated Hospital of Fujian Medical University from January 2010 to December 2023 were included in this retrospective study. Clinicopathological data were collected and analyzed. Results 2,832 patients were enrolled. Primary glomerular diseases accounted for the majority of kidney diseases (69.0%), followed by secondary glomerular diseases, tubulointerstitial diseases, and others. Among primary glomerular diseases, membranous nephropathy (MN) was the most prevalent (34.9%), followed closely by IgA nephropathy (IgAN) (34.5%) and minimal change disease (18.5%), with an increasing trend for MN. For secondary glomerular diseases, lupus nephritis (34.3%), diabetic nephropathy (DN) (24.8%), and hepatitis B virus-associated nephropathy (HBVN) (9.0%) were the most common. HBVN showed a significant decrease, while DN increased annually. Nephrotic syndrome (NS) was the most frequent indication for renal biopsy (40.3%), followed by progressive chronic kidney disease (22.4%). MN (47.2%) was the leading pathology in NS, and IgAN (51.6%) was predominant in patients with proteinuria and hematuria. Conclusions The spectrum of kidney disease has changed within the last 14 years. The relative frequency of MN and DN increased significantly, while that of HBVN decreased significantly. These findings highlight the need for ongoing public health efforts tailored to the changing spectrum of kidney diseases. |
| format | Article |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-7b4df0f0e5df49588b1c75f1ea416ebc2025-08-20T03:18:49ZengPeerJ Inc.PeerJ2167-83592025-04-0113e1930210.7717/peerj.19302Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast ChinaZishan Lin0Shidong Xie1Wenfeng Wang2Tao Hong3Bingjing Jiang4Caiming Chen5Xuan Tao6Dewen Jiang7Jianxin Wan8Hong Chen9Yanfang Xu10Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaObjective Kidney disease has become a significant public health issue. Socioeconomic improvements and environmental changes in China have influenced the kidney disease spectrum. This study aims to examine the changing spectrum of biopsy-confirmed kidney diseases in a single center from southeastern China and explore their clinical-pathological correlations. Methods Patients who underwent renal biopsy at the First Affiliated Hospital of Fujian Medical University from January 2010 to December 2023 were included in this retrospective study. Clinicopathological data were collected and analyzed. Results 2,832 patients were enrolled. Primary glomerular diseases accounted for the majority of kidney diseases (69.0%), followed by secondary glomerular diseases, tubulointerstitial diseases, and others. Among primary glomerular diseases, membranous nephropathy (MN) was the most prevalent (34.9%), followed closely by IgA nephropathy (IgAN) (34.5%) and minimal change disease (18.5%), with an increasing trend for MN. For secondary glomerular diseases, lupus nephritis (34.3%), diabetic nephropathy (DN) (24.8%), and hepatitis B virus-associated nephropathy (HBVN) (9.0%) were the most common. HBVN showed a significant decrease, while DN increased annually. Nephrotic syndrome (NS) was the most frequent indication for renal biopsy (40.3%), followed by progressive chronic kidney disease (22.4%). MN (47.2%) was the leading pathology in NS, and IgAN (51.6%) was predominant in patients with proteinuria and hematuria. Conclusions The spectrum of kidney disease has changed within the last 14 years. The relative frequency of MN and DN increased significantly, while that of HBVN decreased significantly. These findings highlight the need for ongoing public health efforts tailored to the changing spectrum of kidney diseases.https://peerj.com/articles/19302.pdfKidney diseaseRenal biopsyMembranous nephropathyDiabetic nephropathyNephrotic syndrome |
| spellingShingle | Zishan Lin Shidong Xie Wenfeng Wang Tao Hong Bingjing Jiang Caiming Chen Xuan Tao Dewen Jiang Jianxin Wan Hong Chen Yanfang Xu Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast China PeerJ Kidney disease Renal biopsy Membranous nephropathy Diabetic nephropathy Nephrotic syndrome |
| title | Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast China |
| title_full | Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast China |
| title_fullStr | Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast China |
| title_full_unstemmed | Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast China |
| title_short | Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast China |
| title_sort | changes in the spectrum of kidney diseases a 14 year single center retrospective renal biopsy study from southeast china |
| topic | Kidney disease Renal biopsy Membranous nephropathy Diabetic nephropathy Nephrotic syndrome |
| url | https://peerj.com/articles/19302.pdf |
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