Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus)
Abstract Background This study aimed to evaluate the effects of selenium nanoparticles (SeNPs) and/or vitamin E (VE) on the growth, body composition, metabolic parameters, histopathology, and resistance of Nile tilapia to Aspergillus flavus. Results Monosex Nile tilapia fingerlings were sourced from...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12917-025-04471-y |
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| author | Walaa K. Bazina Wesam A. Tawfik Nadia A. Abd Elghany Saadea Saadony Zulhisyam Abdul Kari Muna Omer Alamoudi Mohamed Y. M. Aly Abuelhassan Elshazly Younis Roshmon Thomas Mathew Moaheda E. H. Eissa Mohammad Bodrul Munir Saadiah Ibrahim Ismail Yousef Yusuf O. H. Omar El-Sayed Hemdan Eissa Heba E. Abd Elnabi |
| author_facet | Walaa K. Bazina Wesam A. Tawfik Nadia A. Abd Elghany Saadea Saadony Zulhisyam Abdul Kari Muna Omer Alamoudi Mohamed Y. M. Aly Abuelhassan Elshazly Younis Roshmon Thomas Mathew Moaheda E. H. Eissa Mohammad Bodrul Munir Saadiah Ibrahim Ismail Yousef Yusuf O. H. Omar El-Sayed Hemdan Eissa Heba E. Abd Elnabi |
| author_sort | Walaa K. Bazina |
| collection | DOAJ |
| description | Abstract Background This study aimed to evaluate the effects of selenium nanoparticles (SeNPs) and/or vitamin E (VE) on the growth, body composition, metabolic parameters, histopathology, and resistance of Nile tilapia to Aspergillus flavus. Results Monosex Nile tilapia fingerlings were sourced from the Bazina farm and hatchery in Ismailia Governorate, Egypt, where the experiment was also conducted. The fish were acclimatized for 15 days before the trial. A total of 240 fingerlings (average weight 46 ± 3.0 g/fish) were divided equally across 12 concrete tanks (1 × 1 × 1.2 m, 1 m³ capacity), with 20 fish per tank. The fish were fed a control diet (T0), which was a basal diet with no supplementation, or one of three experimental diets for 60 days: T1 (1 mg SeNPs/kg), T2 (100 mg VE/kg), and T3 (1 mg SeNPs + 100 mg VE/kg). The experiment followed a completely randomized design (CRD) with three replicates per treatment. The combination of SeNPs and VE (T3) resulted in the best feed conversion ratio. A slight but significant increase (P < 0.05) in whole-body composition was observed in all treatment groups compared to the control. Biochemical parameters, serum digestive enzyme activity, and antioxidant levels improved significantly with dietary supplementation. Histopathological analysis revealed somewhat lacerated gill arches in fish fed SeNPs, VE, or their combination, but the overall gill structure remained normal. The SeNPs + VE group exhibited improved villi length and normal morphology of portal veins and hepatic sinusoids, though some vacuolated hepatocytes were noted. Fish in the SeNPs + VE group had the lowest mortality rates and the highest resistance to A. flavus. Conclusion Supplementing diets with SeNPs and/or VE enhances growth, body composition, biochemical parameters, and histopathology in Nile tilapia. The combination of 1 mg SeNPs + 100 mg VE/kg improves immune response and growth, offering a promising strategy to enhance Tilapia health and productivity. |
| format | Article |
| id | doaj-art-7b4d149c27d54eba84d39f0783983056 |
| institution | Kabale University |
| issn | 1746-6148 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Veterinary Research |
| spelling | doaj-art-7b4d149c27d54eba84d39f07839830562025-02-09T12:41:57ZengBMCBMC Veterinary Research1746-61482025-02-0121111210.1186/s12917-025-04471-yEffects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus)Walaa K. Bazina0Wesam A. Tawfik1Nadia A. Abd Elghany2Saadea Saadony3Zulhisyam Abdul Kari4Muna Omer Alamoudi5Mohamed Y. M. Aly6Abuelhassan Elshazly Younis7Roshmon Thomas Mathew8Moaheda E. H. Eissa9Mohammad Bodrul Munir10Saadiah Ibrahim11Ismail Yousef12Yusuf O. H. Omar13El-Sayed Hemdan Eissa14Heba E. Abd Elnabi15National Institute of Oceanography and Fisheries (NIOF)NaQaa Nanotechnology Network (NNN)Fish Diseases Department, Animal Health Research InstituteDepartment of Animal Production and Fish Resources, Faculty of Agriculture, Suez Canal UniversityDepartment of Agricultural Sciences, Faculty of Agro-Based Industry, Universiti Malaysia KelantanBiology Department, Faculty of Science, University of Ha’ilNational Institute of Oceanography and Fisheries (NIOF)Biology Department, Faculty of Science at Yanbu, Taibah UniversityFish Resources Research Center, King Faisal UniversityBiotechnology Department, Fish Farming and Technology Institute, Suez Canal UniversityFaculty of Agriculture, Universiti Islam Sultan Sharif Ali, Sinaut CampusFisheries Research Institute Pulau Sayak, Department of Fisheries Malaysia, Ministry of Agriculture and Food SecurityAquaculture ConsultantDepartment Medicine and Surgery, Faculty of Medicine, Mogadishu UniversityFish Research Centre, Faculty of Environmental Agricultural Sciences, Arish UniversityDepartment of Fish Resources and Aquaculture, Faculty of Environmental Agricultural Sciences, Arish UniversityAbstract Background This study aimed to evaluate the effects of selenium nanoparticles (SeNPs) and/or vitamin E (VE) on the growth, body composition, metabolic parameters, histopathology, and resistance of Nile tilapia to Aspergillus flavus. Results Monosex Nile tilapia fingerlings were sourced from the Bazina farm and hatchery in Ismailia Governorate, Egypt, where the experiment was also conducted. The fish were acclimatized for 15 days before the trial. A total of 240 fingerlings (average weight 46 ± 3.0 g/fish) were divided equally across 12 concrete tanks (1 × 1 × 1.2 m, 1 m³ capacity), with 20 fish per tank. The fish were fed a control diet (T0), which was a basal diet with no supplementation, or one of three experimental diets for 60 days: T1 (1 mg SeNPs/kg), T2 (100 mg VE/kg), and T3 (1 mg SeNPs + 100 mg VE/kg). The experiment followed a completely randomized design (CRD) with three replicates per treatment. The combination of SeNPs and VE (T3) resulted in the best feed conversion ratio. A slight but significant increase (P < 0.05) in whole-body composition was observed in all treatment groups compared to the control. Biochemical parameters, serum digestive enzyme activity, and antioxidant levels improved significantly with dietary supplementation. Histopathological analysis revealed somewhat lacerated gill arches in fish fed SeNPs, VE, or their combination, but the overall gill structure remained normal. The SeNPs + VE group exhibited improved villi length and normal morphology of portal veins and hepatic sinusoids, though some vacuolated hepatocytes were noted. Fish in the SeNPs + VE group had the lowest mortality rates and the highest resistance to A. flavus. Conclusion Supplementing diets with SeNPs and/or VE enhances growth, body composition, biochemical parameters, and histopathology in Nile tilapia. The combination of 1 mg SeNPs + 100 mg VE/kg improves immune response and growth, offering a promising strategy to enhance Tilapia health and productivity.https://doi.org/10.1186/s12917-025-04471-ySelenium nanoparticlesVitamin EOreochromis niloticusBody compositionBiochemical parametersHistopathology |
| spellingShingle | Walaa K. Bazina Wesam A. Tawfik Nadia A. Abd Elghany Saadea Saadony Zulhisyam Abdul Kari Muna Omer Alamoudi Mohamed Y. M. Aly Abuelhassan Elshazly Younis Roshmon Thomas Mathew Moaheda E. H. Eissa Mohammad Bodrul Munir Saadiah Ibrahim Ismail Yousef Yusuf O. H. Omar El-Sayed Hemdan Eissa Heba E. Abd Elnabi Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus) BMC Veterinary Research Selenium nanoparticles Vitamin E Oreochromis niloticus Body composition Biochemical parameters Histopathology |
| title | Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus) |
| title_full | Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus) |
| title_fullStr | Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus) |
| title_full_unstemmed | Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus) |
| title_short | Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus) |
| title_sort | effects of nano selenium and or vitamin e supplementation on growth performance antioxidant status histopathology and resistance to aspergillus flavus in nile tilapia oreochromis niloticus |
| topic | Selenium nanoparticles Vitamin E Oreochromis niloticus Body composition Biochemical parameters Histopathology |
| url | https://doi.org/10.1186/s12917-025-04471-y |
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