Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications
Recognition of the molecular basis of gastrointestinal stromal tumors has paved the way for significant breakthroughs in the diagnosis and treatment of this disease as well as positioned gastrointestinal stromal tumors as a framework for the concept of precision oncology in solid tumors. The incorpo...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2024-05-01
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| Series: | Brazilian Journal of Oncology |
| Subjects: | |
| Online Access: | https://www.brazilianjournalofoncology.com.br/details/278/en-US/gastrointestinal-stromal-tumors--advances-in-molecular-characterization-and-therapeutic-implications |
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| author | Nildevande Firmino Lima-Jr Marcello Moro Queiroz Julia Sousa Leal Franco Domingos Savio do Rego Lins-Junior Eduardo Felício de Campos Beatriz Mendes Awni Luiz Guilherme Cernaglia Aureliano de Lima Frederico Teixeira Fábio de Oliveira Ferreira Eduardo Hiroshi Akaishi Fernanda Cunha Capareli Rodrigo Ramella Munhoz |
| author_facet | Nildevande Firmino Lima-Jr Marcello Moro Queiroz Julia Sousa Leal Franco Domingos Savio do Rego Lins-Junior Eduardo Felício de Campos Beatriz Mendes Awni Luiz Guilherme Cernaglia Aureliano de Lima Frederico Teixeira Fábio de Oliveira Ferreira Eduardo Hiroshi Akaishi Fernanda Cunha Capareli Rodrigo Ramella Munhoz |
| author_sort | Nildevande Firmino Lima-Jr |
| collection | DOAJ |
| description | Recognition of the molecular basis of gastrointestinal stromal tumors has paved the way for significant breakthroughs in the diagnosis and treatment of this disease as well as positioned gastrointestinal stromal tumors as a framework for the concept of precision oncology in solid tumors. The incorporation of novel targeted agents for molecularly defined subgroups has led to significant improvements in treatment outcomes; however, the characterization of heterogeneous KIT or PDGFRA mutations and the emergence of resistance mechanisms highlight the need for a broader use of comprehensive molecular profiling and emphasize the importance of molecularly driven adaptive treatment strategies. Such a molecular background is critical for developing personalized and effective interventions and optimizing outcomes. The present review summarizes key studies that provide the basis for standard-of-care management options as well as provides molecular insights into the management of gastrointestinal stromal tumors, with an emphasis on recent advances. |
| format | Article |
| id | doaj-art-7b4c4e8796894a1da09e29d39411e70c |
| institution | Kabale University |
| issn | 2526-8732 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj-art-7b4c4e8796894a1da09e29d39411e70c2025-08-20T03:35:03ZengThieme Revinter Publicações Ltda.Brazilian Journal of Oncology2526-87322024-05-012010.5935/2526-8732.20240468Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implicationsNildevande Firmino Lima-Jr0Marcello Moro Queiroz1Julia Sousa Leal Franco2Domingos Savio do Rego Lins-Junior3Eduardo Felício de Campos4Beatriz Mendes Awni5Luiz Guilherme Cernaglia Aureliano de Lima6Frederico Teixeira7Fábio de Oliveira Ferreira8Eduardo Hiroshi Akaishi9Fernanda Cunha Capareli10Rodrigo Ramella Munhoz11Hospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilHospital Sirio Libanês, Oncologia Clínica - São Paulo - SP - BrazilRecognition of the molecular basis of gastrointestinal stromal tumors has paved the way for significant breakthroughs in the diagnosis and treatment of this disease as well as positioned gastrointestinal stromal tumors as a framework for the concept of precision oncology in solid tumors. The incorporation of novel targeted agents for molecularly defined subgroups has led to significant improvements in treatment outcomes; however, the characterization of heterogeneous KIT or PDGFRA mutations and the emergence of resistance mechanisms highlight the need for a broader use of comprehensive molecular profiling and emphasize the importance of molecularly driven adaptive treatment strategies. Such a molecular background is critical for developing personalized and effective interventions and optimizing outcomes. The present review summarizes key studies that provide the basis for standard-of-care management options as well as provides molecular insights into the management of gastrointestinal stromal tumors, with an emphasis on recent advances.https://www.brazilianjournalofoncology.com.br/details/278/en-US/gastrointestinal-stromal-tumors--advances-in-molecular-characterization-and-therapeutic-implicationsgastrointestinal stromal tumorssarcomatyrosine kinase inhibitorsproto-oncogene proteins c-kitplatelet-derived growth factor |
| spellingShingle | Nildevande Firmino Lima-Jr Marcello Moro Queiroz Julia Sousa Leal Franco Domingos Savio do Rego Lins-Junior Eduardo Felício de Campos Beatriz Mendes Awni Luiz Guilherme Cernaglia Aureliano de Lima Frederico Teixeira Fábio de Oliveira Ferreira Eduardo Hiroshi Akaishi Fernanda Cunha Capareli Rodrigo Ramella Munhoz Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications Brazilian Journal of Oncology gastrointestinal stromal tumors sarcoma tyrosine kinase inhibitors proto-oncogene proteins c-kit platelet-derived growth factor |
| title | Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications |
| title_full | Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications |
| title_fullStr | Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications |
| title_full_unstemmed | Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications |
| title_short | Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications |
| title_sort | gastrointestinal stromal tumors advances in molecular characterization and therapeutic implications |
| topic | gastrointestinal stromal tumors sarcoma tyrosine kinase inhibitors proto-oncogene proteins c-kit platelet-derived growth factor |
| url | https://www.brazilianjournalofoncology.com.br/details/278/en-US/gastrointestinal-stromal-tumors--advances-in-molecular-characterization-and-therapeutic-implications |
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