Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis
Objectives. To explore the relationship between insulin levels and nonpsychotic dementia. Methods. Six electronic databases (PubMed, Cochrane, SCI, CNKI, VIP, and Wanfang) were searched from January 1, 2007, to March 1, 2017. Experimental or observational studies that enrolled people with nonpsychot...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/1230713 |
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| author | Qiu-xia Pan Xiao-juan Li Yue-yun Liu Fang-fang Wang Ya-jing Hou Qing-lai Bian Wen-qi Qiu Zhi-yi Yan You-ming Jiang Jia-xu Chen |
| author_facet | Qiu-xia Pan Xiao-juan Li Yue-yun Liu Fang-fang Wang Ya-jing Hou Qing-lai Bian Wen-qi Qiu Zhi-yi Yan You-ming Jiang Jia-xu Chen |
| author_sort | Qiu-xia Pan |
| collection | DOAJ |
| description | Objectives. To explore the relationship between insulin levels and nonpsychotic dementia. Methods. Six electronic databases (PubMed, Cochrane, SCI, CNKI, VIP, and Wanfang) were searched from January 1, 2007, to March 1, 2017. Experimental or observational studies that enrolled people with nonpsychotic dementia or abnormal insulin levels in which insulin levels or MMSE scores (events in nonpsychotic dementia) were the outcome measures. Random-effects models were chosen for this meta-analysis. Sample size, mean, s.d., and events were primarily used to generate effect sizes (with the PRIMA registration number CRD42017069860). Results. 50 articles met the final inclusion criteria. Insulin levels in cerebrospinal fluid were lower (Hedges’ g = 1.196, 95% CI = 0.238 to 2.514, and P=0.014), while the levels in peripheral blood were higher in nonpsychotic dementia patients (Hedges’ g = 0.853 and 95% CI = 0.579 to 1.127), and MMSE scores were significantly lower in the high insulin group than in the healthy control group (Hedges’ g = 0.334, 95% CI = 0.249 to 0.419, and P=0.000). Conclusions. Our comprehensive results indicate that blood insulin levels may increase in patients with nonpsychotic dementia. |
| format | Article |
| id | doaj-art-7b453cf1722d4330a4fed41ed2a616dc |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7b453cf1722d4330a4fed41ed2a616dc2025-08-20T02:07:05ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/12307131230713Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-AnalysisQiu-xia Pan0Xiao-juan Li1Yue-yun Liu2Fang-fang Wang3Ya-jing Hou4Qing-lai Bian5Wen-qi Qiu6Zhi-yi Yan7You-ming Jiang8Jia-xu Chen9School of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaObjectives. To explore the relationship between insulin levels and nonpsychotic dementia. Methods. Six electronic databases (PubMed, Cochrane, SCI, CNKI, VIP, and Wanfang) were searched from January 1, 2007, to March 1, 2017. Experimental or observational studies that enrolled people with nonpsychotic dementia or abnormal insulin levels in which insulin levels or MMSE scores (events in nonpsychotic dementia) were the outcome measures. Random-effects models were chosen for this meta-analysis. Sample size, mean, s.d., and events were primarily used to generate effect sizes (with the PRIMA registration number CRD42017069860). Results. 50 articles met the final inclusion criteria. Insulin levels in cerebrospinal fluid were lower (Hedges’ g = 1.196, 95% CI = 0.238 to 2.514, and P=0.014), while the levels in peripheral blood were higher in nonpsychotic dementia patients (Hedges’ g = 0.853 and 95% CI = 0.579 to 1.127), and MMSE scores were significantly lower in the high insulin group than in the healthy control group (Hedges’ g = 0.334, 95% CI = 0.249 to 0.419, and P=0.000). Conclusions. Our comprehensive results indicate that blood insulin levels may increase in patients with nonpsychotic dementia.http://dx.doi.org/10.1155/2017/1230713 |
| spellingShingle | Qiu-xia Pan Xiao-juan Li Yue-yun Liu Fang-fang Wang Ya-jing Hou Qing-lai Bian Wen-qi Qiu Zhi-yi Yan You-ming Jiang Jia-xu Chen Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis Neural Plasticity |
| title | Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis |
| title_full | Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis |
| title_fullStr | Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis |
| title_short | Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis |
| title_sort | relationship between insulin levels and nonpsychotic dementia a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2017/1230713 |
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