Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques

Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques

A clinical need exists for more effective intravitreal (IVT) drug delivery systems (DDS). This study tested the hypothesis that a novel biodegradable, injectable microsphere-hydrogel drug delivery system loaded with aflibercept (aflibercept-DDS) would exhibit long-term safety and biocompatibility in...

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Bibliographic Details
Main Authors: Brett D. Story, Sangwan Park, Karolina Roszak, Jaeho Shim, Monica Motta, Michelle Ferneding, Kayla M. Rudeen, Andrew Blandino, Monica Ardon, Sophie Le, Leandro B. C. Teixeira, Glenn Yiu, William F. Mieler, Sara M. Thomasy, Jennifer J. Kang-Mieler
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Drug Delivery
Subjects:
aflibercept
anti-VEGF
controlled drug delivery
intravitreal injection
nonhuman primate
thermo-responsive hydrogel
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2025.2460671
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