Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial
Background: There is evidence that pomegranate juice and sildenafil can be effective supplements especially in pregnancy. Therefore; this study aimed to compare the effect of pomegranate juice and sildenafil on Doppler ultrasound findings, Apgar score and fetal estimated weight (FEW) in cases with...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2025-04-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | https://www.ijfs.ir/article_718411_d138ae8a3193c39dc378f477c8cab5a8.pdf |
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| author | Khadijeh Nasri Fatemeh Ghaedi Fatemeh Safi SeyedAmirhossein Latifi Amir Almasi-Hashiani |
| author_facet | Khadijeh Nasri Fatemeh Ghaedi Fatemeh Safi SeyedAmirhossein Latifi Amir Almasi-Hashiani |
| author_sort | Khadijeh Nasri |
| collection | DOAJ |
| description | Background: There is evidence that pomegranate juice and sildenafil can be effective supplements especially in pregnancy. Therefore; this study aimed to compare the effect of pomegranate juice and sildenafil on Doppler ultrasound findings, Apgar score and fetal estimated weight (FEW) in cases with intrauterine growth retardation (IUGR).Materials and Methods: This randomized clinical trial conducted on a population of naturally pregnant women with IUGR in Arak city (Arak, Iran) during October 2021 to January 2022. Participants were randomly divided into two equal groups (n=27) that received pomegranate juice (230 ml daily dose for 6 weeks, Narnoosh, Arak, Iran) and sildenafil (25 mg, three times a day for 6 weeks, Marham Daru Co., Tehran, Iran). Doppler ultrasound evaluation, including umbilical artery pulsatility index (PI), uterine artery PI and FEW were assessed by a gynecologic resident along with a radiologist immediately after intervention, and birth weight and 1- and 5-minute Apgar scores were registered by a neonatologist.Results: Twenty-one cases in pomegranate juice group and 23 cases in sildenafil group were included in the analysis. The mean age and weight of participants were 27.1 ± 4.7 year and 68.5 ± 11.5 kg, respectively. The results showed that there was no significant difference between the two groups in terms of mean Apgar score of 1 minute (P=0.631), 5 minutes (P=0.323) and birth weight (P=0.580). No significant difference was observed between two groups in terms of uterine artery PI (P=0.301) and umbilical artery PI (P=0.168), but the EFW changes in the sildenafil group were significantly greater than the pomegranate group (P=0.009).Conclusion: The results of our study showed that pomegranate juice has a similar effect of sildenafil in IUGR. Therefore, it is recommended to design more studies to achieve results that are more valid (registration number: IRCT20210730052014N1). |
| format | Article |
| id | doaj-art-7b3d79b5110b472ca84dbfadbbaa23b3 |
| institution | OA Journals |
| issn | 2008-076X 2008-0778 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj-art-7b3d79b5110b472ca84dbfadbbaa23b32025-08-20T02:08:28ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782025-04-0119223624010.22074/ijfs.2024.2015922.1574718411Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled TrialKhadijeh Nasri0Fatemeh Ghaedi1Fatemeh Safi2SeyedAmirhossein Latifi3Amir Almasi-Hashiani4Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, IranStudent Research Committee, Arak University of Medical Sciences, Arak, IranDepartment of Radiology and Radiotherapy, School of Medicine, Arak University of Medical Sciences, Arak, IranTraditional and Complementary Medicine Research Center, School of Medicine, Arak University of Medical Sciences, Arak, IranTraditional and Complementary Medicine Research Center, School of Medicine, Arak University of Medical Sciences, Arak, IranBackground: There is evidence that pomegranate juice and sildenafil can be effective supplements especially in pregnancy. Therefore; this study aimed to compare the effect of pomegranate juice and sildenafil on Doppler ultrasound findings, Apgar score and fetal estimated weight (FEW) in cases with intrauterine growth retardation (IUGR).Materials and Methods: This randomized clinical trial conducted on a population of naturally pregnant women with IUGR in Arak city (Arak, Iran) during October 2021 to January 2022. Participants were randomly divided into two equal groups (n=27) that received pomegranate juice (230 ml daily dose for 6 weeks, Narnoosh, Arak, Iran) and sildenafil (25 mg, three times a day for 6 weeks, Marham Daru Co., Tehran, Iran). Doppler ultrasound evaluation, including umbilical artery pulsatility index (PI), uterine artery PI and FEW were assessed by a gynecologic resident along with a radiologist immediately after intervention, and birth weight and 1- and 5-minute Apgar scores were registered by a neonatologist.Results: Twenty-one cases in pomegranate juice group and 23 cases in sildenafil group were included in the analysis. The mean age and weight of participants were 27.1 ± 4.7 year and 68.5 ± 11.5 kg, respectively. The results showed that there was no significant difference between the two groups in terms of mean Apgar score of 1 minute (P=0.631), 5 minutes (P=0.323) and birth weight (P=0.580). No significant difference was observed between two groups in terms of uterine artery PI (P=0.301) and umbilical artery PI (P=0.168), but the EFW changes in the sildenafil group were significantly greater than the pomegranate group (P=0.009).Conclusion: The results of our study showed that pomegranate juice has a similar effect of sildenafil in IUGR. Therefore, it is recommended to design more studies to achieve results that are more valid (registration number: IRCT20210730052014N1).https://www.ijfs.ir/article_718411_d138ae8a3193c39dc378f477c8cab5a8.pdfdopplerfetal growth retardationpomegranatesildenafil citrateultrasonography |
| spellingShingle | Khadijeh Nasri Fatemeh Ghaedi Fatemeh Safi SeyedAmirhossein Latifi Amir Almasi-Hashiani Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial International Journal of Fertility and Sterility doppler fetal growth retardation pomegranate sildenafil citrate ultrasonography |
| title | Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial |
| title_full | Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial |
| title_fullStr | Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial |
| title_full_unstemmed | Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial |
| title_short | Effect of Pomegranate Juice and Sildenafil on Intrauterine Growth Retardation: A Randomized Controlled Trial |
| title_sort | effect of pomegranate juice and sildenafil on intrauterine growth retardation a randomized controlled trial |
| topic | doppler fetal growth retardation pomegranate sildenafil citrate ultrasonography |
| url | https://www.ijfs.ir/article_718411_d138ae8a3193c39dc378f477c8cab5a8.pdf |
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